Pancreatic Cancer News

November 23, 2024

Top Headlines

Protein Degradation Strategy Offers New Hope in Cancer Therapy

Nov. 11, 2024 — A team of scientists has used a novel approach to identify protein degraders that target Pin1, a protein involved in pancreatic cancer ...

Researchers Uncover New Role of Mutant Proteins in Some of the Deadliest Cancers

Nov. 11, 2024 — Researchers have discovered a new way in which RAS genes, which are commonly mutated in cancer, may drive tumor growth beyond their well-known role in signaling at the cell surface. Mutant RAS, they ...

How the Immune System Fails as Cancer Arises

Sep. 12, 2024 — Scientists discovered a targetable molecule that reprograms immune cells and turns them into cancer ...

Pancreatic Cancer: Study Finds Most Early Staging Inaccurate

Sep. 5, 2024 — Staging of patients with early pancreatic cancer is inaccurate as much as 80% of the time, according to a new study. The finding underscores the urgent need for advancements in diagnostic technology and staging, which could significantly alter early ...

Latest Headlines

updated 10:45pm EST

Insights Into KRAS Mutations in Pancreatic Cancers

Oct. 2, 2024 — A common mutation in the KRAS gene is associated with improved overall survival in pancreatic ductal adenocarcinoma (PDAC) compared with other variants, in part because the mutation appears to lead ...

Insulin Cells Don't Need to Team Up

Sep. 3, 2024 — Our glycaemic balance is based on the ability of the pancreatic beta cells to detect glucose and secrete insulin to maintain our blood sugar levels. If these cells malfunction, the balance is broken, ...

New Pancreatic Cancer Treatment Proves Effective in Shrinking, Clearing Tumors

Aug. 28, 2024 — Researchers have demonstrated in mice a new method to combat pancreatic cancer. The study outlines the synergistic effects of a novel nanoparticle ...

New Anti-CKAP4 Antibodies Deliver Hope for Pancreatic Cancer Treatment

Aug. 20, 2024 — Researchers have developed an antibody that prevents the activation of the Dickkopf 1-Cytoskeleton-associated protein 4 (DKK1-CKAP4) pathway, which is important for tumor growth in several cancers, ...

A Ketogenic Diet Could Improve the Response to Pancreatic Cancer Therapy

Aug. 14, 2024 — Scientists have discovered a way to get rid of pancreatic cancer in mice by putting them on a high fat, or ketogenic, diet and giving them cancer ...

Faster Detection of Pancreatic Cancer

Aug. 9, 2024 — Pancreatic cancer is one of the most lethal forms of cancer, primarily because it is usually diagnosed very late. Current markers are too insensitive and unspecific for early detection screenings. A ...

Discovery Suggests Opportunity to Improve Effectiveness of KRAS Inhibitors Against Pancreatic Cancer

July 11, 2024 — Researchers discovered a new mechanism of resistance to KRAS inhibitors that suggests an opportunity to make the treatment more ...

AI Model to Improve Patient Response to Cancer Therapy

July 3, 2024 — A new artificial intelligence tool that can help to select the most suitable treatment for cancer patients has been ...

Chemotherapy Before Surgery Benefits Some Patients With Pancreatic Cancer

June 20, 2024 — Patients with pancreatic cancer who received chemotherapy both before and after surgery experienced longer survival rates than would be expected from surgery followed by chemotherapy, according to a ...

New 3D Technique Reveals Precancerous Pancreatic Lesions

June 18, 2024 — Researchers have developed a 3D genomic profiling technique to identify small precancerous lesions in the pancreas -- called pancreatic intraepithelial neoplasias (PanINs) -- that lead to one of the ...

New Cancer Diagnoses Did Not Rebound as Expected Following Pandemic

Sep. 24, 2024 — Cancer incidence trends in 2021 largely returned to what they were before the COVID-19 pandemic, according to a study by researchers at the National Institutes of Health (NIH). However, there was ...

Old Chemo Drug, New Pancreatic Cancer Therapy?

Aug. 26, 2024 — Researchers discovered that treating pancreatic cancer with a common chemotherapy drug makes immunotherapy more effective. Folinic acid elevates levels of two anti-cancer immune molecules within ...

Gene That Helps Cancer Cells Spread Throughout the Body

June 11, 2024 — Expression of Gstt1 enables the cells to change the surrounding environment to support their growth. The findings could lead to new strategies to treat metastatic cancer and would be particularly ...

Molecular Pathway That Impacts Pancreatic Cancer Progression and Response to Treatment Detailed

June 6, 2024 — Researchers have established the most comprehensive molecular portrait of the workings of KRAS, a key cancer-causing gene or 'oncogene,' and how its activities impact pancreatic cancer ...

Breaking Down Barriers: ROCK2 Inhibition Facilitates Drug Delivery in Fibrotic Pancreatic Cancer

June 6, 2024 — Scientists developed a human pancreatic cancer fibrotic barrier 3D cell-culture model to assess treatments for pancreatic ductal adenocarcinoma. By targeting the ROCK2 pathway, they achieved a ...

Statin Therapy May Prevent Cancer by Blocking Inflammatory Protein

May 30, 2024 — Scientists have found that statins -- commonly used cholesterol-lowering drugs -- may block a pathway that leads to the development of cancer in the context of chronic ...

Strengthening CAR-T Therapy to Work Against Solid Tumors

May 8, 2024 — Researchers have shown that a breakthrough therapy for treating blood cancers can be adapted to treat solid tumors -- an advance that could transform cancer treatment. The promising findings involve ...

Difference Found in Pancreatic Cancer Cells, Offering New Hope for Immunotherapy Effectiveness

Apr. 30, 2024 — A new study has found that pancreatic cancer cells are different based on their location in the pancreas, providing new information about tumors that could lead to better targeted ...

Scientists Uncover Key Resistance Mechanism to Wnt Inhibitors in Pancreatic and Colorectal Cancers

Apr. 11, 2024 — A new study reveals why some pancreatic and colorectal tumors resist targeted anti-Wnt drugs and suggests how to overcome it, offering new hope to patients with fully treatment-resistant ...

Opening a New Front Against Pancreatic Cancer

Apr. 8, 2024 — A new type of investigational therapeutic for pancreatic cancer has shown unprecedented tumor-fighting abilities in preclinical models of the ...

Study Finds Less Invasive, Safer Option for Removing Benign Pancreatic Tumors

Apr. 4, 2024 — Researchers describe a new technique for the minimally invasive removal of benign tumors located in the challenging posterior head of the pancreas (right side of abdomen, nestled in the curve of the ...

A Smart Molecule Beats the Mutation Behind Most Pancreatic Cancer

Mar. 5, 2024 — Researchers have designed a candidate drug that could help make pancreatic cancer, which is almost always fatal, a treatable, perhaps even curable, ...

Pancreatic Cancer Lives on Mucus

Feb. 28, 2024 — Our bodies depend on mucus to function properly. As it turns out, so do some cancer cells. Scientists discovered mucus not only allows young pancreatic cancer cells to grow, but also prevents them ...

Feb. 20, 2024 — Older people may be at greater risk of developing pancreatic cancer and have poorer prognoses because of age-related changes in cells in the pancreas called fibroblasts, according to new ...

Pancreatic Cancer Hijacks a Brain-Building Protein

Feb. 14, 2024 — Scientists have discovered that pancreatic ductal adenocarcinoma (PDAC) hijacks a protein called EN-1 to evade cancer-fighting genes during metastasis. Future drugs targeting EN-1 or related proteins ...

Study Suggests That Unintentional Weight Loss Is a Signal to See a Doctor

Jan. 23, 2024 — Unintentional weight loss is associated with an increase in the risk of a cancer diagnosis within the coming year, according to a new study. Compared with participants who did not lose weight, recent ...

Targeting Annexin-A1 Can Halt Cancer Cell Growth

Jan. 19, 2024 — A new study highlights the effectiveness of MDX-124, the first therapeutic drug to target annexin-A1, a protein which is overexpressed in several cancer types and promotes tumor ...

Deregulation of Alternative RNA Splicing Promotes Pancreatic Cancer Progression and Metastasis

Jan. 13, 2024 — In a new study, researchers demonstrate that deregulation of a protein called RBFOX2, involved in RNA splicing, contributes to the progression and metastasis of pancreatic ...

Scientists Use Organoid Model to Identify Potential New Pancreatic Cancer Treatment

Dec. 27, 2023 — A drug screening system that models cancers using lab-grown tissues called organoids has helped uncover a promising target for future pancreatic cancer ...

Promising Anticancer Drug Targeting KRAS Protein

Dec. 18, 2023 — A team of scientists has successfully developed a groundbreaking targeted therapy that hones in on the KRAS protein that drives some of the deadliest human cancers, including pancreatic, lung and ...