Personalized Medicine News

January 29, 2025

Top Headlines

Inherited Gene Elevates Prostate Cancer Risk in Affected Families

Jan. 28, 2025 — The inherited mutated gene WNT9B, which functions normally in embryonic prostate development, increases risk of adult prostate cancer, according to a new ...

Genetic 'Fingerprint' to Predict Drug Resistance in Bacteria

Jan. 28, 2025 — New research has identified a unique genetic signature in bacteria that can predict their likelihood of developing antibiotic resistance, a finding that can help quickly identify precision-based treatments that are more effective against the deadly, ...

Combination of Dual-Targeted Therapies and Chemotherapy Shows High Response Rates in BRAF-Mutated Metastatic Colorectal Cancer

Jan. 25, 2025 — Patients with metastatic colorectal cancer (mCRC) harboring BRAF V600E mutations benefited from first-line treatment with the targeted therapies encorafenib and cetuximab plus a mFOLFOX6 chemotherapy ...

Predicting How Childhood Kidney Cancers Develop

Jan. 23, 2025 — New research looked at how cancers arise in children who are predisposed to developing the childhood kidney cancer, Wilms tumor, which could help anticipate the development of tumors before they fully ...

Latest Headlines

updated 12:56pm EST

How Your Brain Learns from Rewards Might Hold the Key to Treating Depression

Jan. 22, 2025 — Using computational models, the researchers studied how the brain's reward-learning system functions in those with depression, especially among ...

Monitoring Tumor-Informed Circulating Tumor DNA After CGP

Jan. 15, 2025 — A research team proposes a method to assess cancer patients for their likelihood to either respond to treatment or ...

SCP-Nano: A New Technology to Visualize Nanocarriers in Cells and Tissues

Jan. 14, 2025 — How can we ensure that life-saving drugs or genetic therapies reach their intended target cells without causing harmful side effects? Researchers have taken an important step to answer this question. ...

Scientists Identify Genes Driving Cancer Spread

Jan. 9, 2025 — Cancer metastasis -- the spread of cancer to other organs -- is the leading cause of death among cancer patients. Researchers have now uncovered a 'genetic signature' of 177 genes shared across ...

Researchers Resolve Uncertainty in BRCA2 Testing, Improving Cancer Risk Assessment and Patient Care

Jan. 8, 2025 — Findings from a multi-institutional, international study have significantly advanced the understanding of genetic alterations in the BRCA2 gene, a ...

Discovery Links Cellular Structures to Kidney Cancer Treatment Outcomes

Jan. 2, 2025 — Fighting cancer can seem like a deadly game of chance. While some patients may respond well to certain treatments, others might not be as fortunate. Doctors and scientists have long struggled to ...

Study Finds New Blood Test Predicts Prognosis for Advanced Prostate Cancer Patients

Dec. 11, 2024 — A new study found that a DNA sequencing test for advanced prostate cancer patients can distinguish between patients with poor and favorable ...

Brain Tumor Organoids Accurately Model Patient Response to CAR T Cell Therapy

Dec. 9, 2024 — Researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient's response to CAR T ...

Personalized Blood Count Could Lead to Early Intervention for Common Diseases

Dec. 11, 2024 — A complete blood count (CBC) screening is a routine exam requested by most physicians for healthy adults. Currently, the results of CBC tests are ...

Genetic Data from 'Biobanks' May Help Improve Prediction of Effectiveness, Side Effects of Common Medications

Dec. 4, 2024 — A new study has outlined a new framework that researchers say would improve predictive power of genetics to determine how well a patient would ...

Genetic Testing Changes Course of Care in Children With Neurodevelopmental Conditions

Dec. 18, 2024 — Adding genetic testing to the evaluation of pediatric patients with neurodevelopmental disorders (NDD) resulted in more individualized ...

Largest-Ever Exome Study Offers Blueprint for Biomedical Breakthroughs

Dec. 3, 2024 — Scientists have achieved a significant milestone generating a large collection of exome data, which include genes that code for proteins -- key to understanding health and ...

Genetic Variation Enhances Cancer Drug Sensitivity

Nov. 14, 2024 — By exploiting the genetic variation in cancer cells, an already approved cancer drug demonstrated enhanced effects against cancer cells in specific patient groups, according to a new study. The ...

Genomic Databases Need More Diversity, Experts Say

Nov. 6, 2024 — Researchers have developed a broad and deep genomic database of Latin Americans which gathers genome-wide data of Latin American populations into a single source and allows other scientists to easily ...

Precision Robotics Offers Hope for Heart Disease Treatment

Oct. 30, 2024 — The advanced drug testing system screens multiple potential therapies simultaneously in beating heart ...

New Method to Analyze Complex Genetic Data Could Be the Key to Tackling Rare Diseases

Oct. 30, 2024 — Scientists have developed a new method of genetic analysis, which extracts more precise data than previously used methods when looking at DNA, and will improve our understanding of the genetic basis ...

Using AI to Measure Prostate Cancer Lesions Could Aid Diagnosis and Treatment

Oct. 29, 2024 — Prostate cancer is the second most common cancer in men, and almost 300,000 individuals are diagnosed with it each year in the U.S. To develop a consistent method of estimating prostate cancer size, ...

New Research Could Lead to Genetically Tailored Diets to Treat Patients With IBS

Oct. 21, 2024 — An international study has found that genetic variations in human carbohydrate-active enzymes may affect how people with irritable bowel syndrome (IBS) respond to a carbohydrate-reduced ...

Large-Scale Study of Children With Genetic Disorders Finds Huge Benefit of Diagnosis

Oct. 15, 2024 — Genetic results from the Deciphering Developmental Disorders (DDD) study have enabled thousands of children with severe developmental disorders to receive better ...

Researchers Identify Neurodevelopmental Symptoms That Indicate Genetic Disorders

Oct. 11, 2024 — Researchers have found that motor delay and low muscle tone were common signs of an underlying genetic diagnosis in children with neurodevelopment ...

Genetic Analysis of 25,000 Chinese Mothers and Infants Reveals Unique Genes Associated With Disease Risk

Oct. 9, 2024 — Genome-wide association studies have great potential for advancing our understanding of the genetic background of diseases, but so far, few association studies have focused on maternal and newborn ...

Research Points to Potential New Treatment for Aggressive Prostate Cancer Subtype

Oct. 4, 2024 — Researchers describe the mechanisms of how alterations in the CDK12 gene drive prostate cancer development and report on a promising degrader that targets CDK12 and a related gene to destroy ...

Sep. 30, 2024 — An innovative analysis of shared segments within the genome -- an indication of distant 'relatedness' -- has identified undiagnosed cases of Long QT syndrome, a rare disorder that can lead ...

Single-Dose Gene Therapy Is Potentially Life-Changing for Adults With Hemophilia B

Sep. 25, 2024 — Adults with hemophilia B saw their number of bleeding episodes drop by an average of 71 percent after a single infusion of gene therapy, according to the new results of an international Phase III ...

How Do Rare Genetic Variants Affect Health? AI Provides More Accurate Predictions

Sep. 25, 2024 — Researchers have introduced an algorithm based on deep learning that can predict the effects of rare genetic variants. The method allows persons with high risk of disease to be distinguished more ...

New Insights Into Intellectual Disability Genetics Emerge

Sep. 23, 2024 — Researchers have published a pivotal study that sheds light on a novel genetic variant associated with intellectual capacities and educational outcomes. This discovery offers new insights into ...

Unlocking the Potential of Patient-Derived Organoids for Personalized Sarcoma Treatment

Sep. 20, 2024 — Investigators developed the largest collection of sarcoma patient-derived organoids to date that can help improve the understanding of the disease and better identify therapies that are most likely ...

Breast and Ovarian Cancer Newly Linked to Thousands of Gene Variants

Sep. 18, 2024 — New research identifies specific genetic changes that can increase a person's risk of breast and ovarian cancers, to help guide clinical ...

Kidney Models-on-a-Chip Taking a Step Toward Personalized Medicine

Sep. 18, 2024 — A team developed a human iPS cell-derived kidney organoid-based proximal tubule-on-chip -- OPTECs-on-Chip -- that mimics in vivo renal physiology more closely than ever before. This model exhibits ...

Immunotherapy Shows Promise for Men With Specific Types of Prostate Cancer

Sep. 16, 2024 — New research has shown that immunotherapy can be effective in treating prostate cancer in men who are selected based on the genetic characteristics of their tumors. In a recent study, it was found ...