Stem Cells News

April 12, 2025

Top Headlines

Driving the CAR to Fight Acute Myeloid Leukemia

Apr. 11, 2025 — A multi-institutional team developed a chimeric antigen receptor (CAR) T cell-based strategy for specifically targeting AML cells in patients who relapsed following other treatments. The team identified a monoclonal antibody called KG2032 that ...

NK Cells Complexed With Bispecific Antibody Yield High Response Rates in Patients With Lymphoma

Apr. 4, 2025 — A novel cell therapy approach using cord blood-derived natural killer (NK) cells pre-complexed with AFM13, or acimtamig, a CD30/CD16A bispecific antibody, was safe and generated strong response rates ...

Drug-Delivering Aptamers Target Leukemia Stem Cells for One-Two Knockout Punch

Apr. 3, 2025 — Drug-carrying DNA aptamers can deliver a one-two punch to leukemia by precisely targeting the elusive cancer stem cells that seed cancer relapses, researchers report. The aptamers -- short ...

How the Brain and Inner Ear Are Formed

Apr. 3, 2025 — Researchers have developed a method that shows how the nervous system and sensory organs are formed in an embryo. By labeling stem cells with a genetic 'barcode', they have been able to follow the cells' developmental journey and discover how the ...

Latest Headlines

updated 10:53pm EDT

Target to Repair Injured Muscles Discovered

Mar. 26, 2025 — A team has discovered a possible therapeutic approach to repair injured muscles either from aging or degenerative muscle ...

'Switch' Allows Intestinal Cells to Regenerate After Injury

Mar. 25, 2025 — Researchers have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer. A professor of pediatrics-developmental biology and an assistant professor of ...

Nursery of the Blood: How Stem Cells Calm the Body's Immune Response

Mar. 21, 2025 — Our blood consists of many cell types that develop through different stages from a precursor type -- the blood stem cell. An international research team has now investigated the developmental ...

Scientists Use Cellular Programming to Mimic First Days of Embryonic Development

Mar. 20, 2025 — Using CRISPR-based engineering methods to prompt stem cells to organize into embryo-like structures, scientists were able to create 'programmable' ...

Shaping the Future of Diabetes Treatment With 3D Bioprinting Technology

Mar. 19, 2025 — An innovative platform replicates pancreatic functions, transforming diabetes ...

Specialized Blood Vessels and Nitric Oxide Found to Be Key to Stem Cell Survival and Immune Evasion

Mar. 12, 2025 — Scientists have made an important discovery about the relationship between hematopoietic stem cells (HSCs) and immune response evasion. Their ...

Beneficial Genetic Changes Observed in Regular Blood Donors

Mar. 11, 2025 — Researchers have identified genetic changes in blood stem cells from frequent blood donors that support the production of new, non-cancerous cells. Understanding the differences in the mutations that ...

FLIpping the Switch: Boosting Stem Cell Numbers for Therapies

Mar. 10, 2025 — A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce new blood cells, according to a preclinical study. The discovery could lead ...

When You Get Hurt Matters: Circadian Rhythms Affect Muscle Repair

Mar. 5, 2025 — The body's internal clock doesn't just dictate when we sleep -- it also determines how quickly our muscles heal. A new study in mice suggests that muscle injuries heal faster when they occur during ...

How Our Lungs Back Up the Bone Marrow to Make Our Blood

Feb. 27, 2025 — Red blood cells carry oxygen from the lungs to every other organ, and blood-forming stem cells must make about 200 billion new red blood cells each day to keep the oxygen flowing. For many years, ...

Key Protein Identified for Understanding and Treating Alzheimer's Disease

Feb. 28, 2025 — Researchers have identified a specific form of the tau protein that is responsible for mediating the toxicity of harmful protein clumps in human neurons and thus represents a target for future ...

Stem Cell Transplant Clears Clinical Safety Hurdle for the Treatment of Wet Age-Related Macular Degeneration

Feb. 27, 2025 — Wet AMD in its early stages can be treated with drugs to reduce the formation of new blood vessels, but this treatment is inefficient in cases where blood vessel formation is already in its advanced ...

Cell Connects: Breaking Barriers in Stem Cell Communication Through mRNA Transfer

Feb. 19, 2025 — Messenger RNA can travel between different types of stem cells through tunnel-like structures, as revealed by a new study. By studying interactions between mouse and human stem cells, they discovered ...

Disruption of a Single Amino Acid in a Cellular Protein Makes Breast Cancer Cells Behave Like Stem Cells

Feb. 11, 2025 — Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an oestrogen independent manner. Targeting vimentin and/or the long ...

Uncovering How Developmental Genes Are Held in a Poised State

Feb. 6, 2025 — New research has investigated the mechanism by which bivalency functions to poise genes for expression during cell differentiation, providing insight into a long-standing paradigm in the regulation ...

How Healthy Stem Cells Turn Into Oral Cancer

Feb. 4, 2025 — Researchers have identified the molecular and cellular mechanisms that transform healthy stem cells into oral cancer at the earliest stages of the ...

Breakthrough in Childhood Brain Cancer Research Could Heal Treatment-Resistant Tumors, Keep Them in Remission

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice. The novel drug CT-179 ...

Research Discovery Halts Childhood Brain Tumor Before It Forms

Feb. 4, 2025 — A research team has identified a critical event driving tumor growth in a type of medulloblastoma -- and a way to block ...

New Research Unlocks Key to Long-Lasting Immune Response in Cancer and Chronic Diseases

Jan. 31, 2025 — Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders -- T cells -- lose their ability to function effectively. ...

First Mouse With Two Male Parents to Reach Adulthood

Jan. 28, 2025 — A team of stem cell scientists have successfully used embryonic stem cell engineering to create a bi-paternal mouse -- a mouse with two male parents -- that lived until adulthood. Their results ...

Immune Complex Shaves Stem Cells to Protect Against Cancer

Jan. 17, 2025 — A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, ...

DNA Damage Can Last Unrepaired for Years, Changing Our View of Mutations

Jan. 15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

Building a Backbone: Scientists Recreate the Body's 'GPS System' in the Lab

Dec. 18, 2024 — Scientists have generated human stem cell models which contain notochord -- a tissue in the developing embryo that acts like a navigation system, directing cells where to build the spine and nervous ...

Brain Cells Remain Healthy After a Month on the International Space Station, but Mature Faster Than Brain Cells on Earth

Dec. 17, 2024 — Microgravity is known to alter the muscles, bones, the immune system and cogni tion, but little is known about its specific impact on the brain. To discover how brain cells respond to microgravity, ...

Neural Stem Cell Transplantation Shows Promise for Treating Chronic Spinal Cord Injury

Dec. 17, 2024 — Using neural stem cells could help treat spinal injuries once thought to be untreatable -- a new phase 1 trial has determined this approach is ...

New Drug Shows Promise Against Duchenne Muscular Dystrophy

Dec. 16, 2024 — A novel drug holds promise for treating Duchenne muscular dystrophy (DMD), a rare genetic disorder that causes severe muscle degeneration. Researchers have discovered that an experimental compound ...

Intermittent Fasting Inhibits Hair Regeneration in Mice

Dec. 13, 2024 — Intermittent fasting has proven benefits for metabolic health, but a new study shows that it could slow hair growth -- at least in mice. Researchers report that mice subjected to intermittent fasting ...

The Maternal Microbiome During Pregnancy Impacts Offspring's Stem Cells in Mice

Dec. 11, 2024 — Gut microbiome composition during pregnancy has long-term effects on offspring stem cell growth and development, researchers report. Treating pregnant mice with a common gut microbe resulted in ...

Study Breaks the Silence on How Fish and Lizards Regenerate Hearing

Dec. 9, 2024 — A new study has identified key gene regulators that enable some deafened animals -- including fish and lizards -- to naturally regenerate their hearing. The findings could guide future efforts to ...

Nr1h2: A Key Transcription Factor Unlocks New Potential in Stem Cell-Based Embryo Models

Dec. 6, 2024 — Researchers have identified Nr1h2, a critical transcription factor essential for early embryo development. Their findings enhance our understanding of gene regulation during blastoid formation and ...