July 17, 2023 Chronic inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis, is on the rise worldwide. The benefits of current medications are limited by problematic side effects. A ...
July 5, 2023 A study of the genetic variation that makes mice more susceptible to bowel inflammation after a high-fat diet has identified candidate genes which may drive inflammatory bowel disease (IBD) in ...
July 3, 2023 A new study shows the sugar sialic acid, which makes up part of the protective intestinal mucus layer, fuels disease-causing bacteria in the gut. The findings suggest a potential treatment target for ...
June 21, 2023 Probiotics can help maintain a healthy gut microbiome or restore populations of 'good bacteria' after a heavy course of antibiotics. But now, they could also be used as an effective ...
June 8, 2023 For the first time, cells involved with the communication between stress responses in the brain and inflammation in the gastrointestinal (GI) tract have been identified in animal models. Glial cells, ...
Apr. 20, 2023 Investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease. The variant ...
Apr. 7, 2023 A new study could help improve personalized medicine approaches in inflammatory bowel disease by understanding how patients with variants in the PTPN2 gene develop ...
Apr. 4, 2023 Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn's ...
Mar. 31, 2023 Researchers have succeeded in developing an E. coli-based 'smart microbe' that secretes therapeutic payloads, including antibodies, into the gut. The genetically modified beneficial strain ...
Feb. 28, 2023 Inflammatory diseases like rheumatoid arthritis have complex disease mechanisms that can differ from patient to patient with the same diagnosis. This means that currently available drugs have little ...
Feb. 23, 2023 Psyllium fiber protects against ulcerative colitis and suppresses inflammation by activating the bile acid nuclear receptor, a mechanism that was previously unrecognized, according to a new ...
Dec. 12, 2022 A new drug acts like a master reset switch in the intestines. The compound, called FexD, has previously been found to lower cholesterol, burn fat, and ward off colorectal cancer in mice. Now, the ...
Dec. 8, 2022 Commonly used drugs that reduce joint inflammation in patients with rheumatoid arthritis also reduce vascular inflammation and cardiovascular risk, finds a new ...
Dec. 2, 2022 B cells are critical to the proper functioning of the immune system. However, researchers have shown that they can sometimes do more harm than good, as their numbers greatly increase after bowel ...
Dec. 1, 2022 Changes in a single gene open the door for harmful gut bacteria to set off the inflammation that drives Crohn's disease, according to a new study. These findings could one day help doctors ...
Nov. 7, 2022 Inflammatory bowel disease is a risk factor for giving birth preterm even when in apparent disease remission, a new study shows. If corroborated, the results may eventually affect recommendations for ...
Nov. 1, 2022 Bacteria in the small intestine adapt dynamically to our nutritional state, with individual species disappearing and reappearing. Researchers have now been able to comprehensively study the bacteria ...
Sep. 8, 2022 Scientists have identified a protein known as sulfatase-2 that plays a critical role in the damage caused by rheumatoid arthritis. The researchers' discovery sheds new light on the molecular ...
Aug. 29, 2022 An international consortium of researchers has identified genetic variants in 10 genes that elevate a person's susceptibility to Crohn's disease, a form of inflammatory bowel disease. The ...
Aug. 25, 2022 Immunologists have identified an important intermediate step in innate immune ...