Personalized Medicine News

April 17, 2024

Top Headlines

Melanomas Resist Drugs by 'Breaking' Genes

Apr. 12, 2024 — A study has disentangled the mechanisms behind one of the ways melanoma cancer cells develop resistance to treatment. The study found that, in response to some drugs, melanomas can 'break' parts of their BRAF gene, which is mutated in 1 in 2 ...

Researchers Identify New Genetic Risk Factors for Persistent HPV Infections

Apr. 11, 2024 — Human papillomavirus (HPV) is the second most common cancer-causing virus, accounting for 690,000 cervical and other cancers each year worldwide. While the immune system usually clears HPV infections, those that persist can lead to cancer, and a new ...

New Insight Into Combating Drug-Resistant Prostate Cancer

Apr. 10, 2024 — New research sheds light on the significance of the glucocorticoid receptor in drug-resistant prostate cancer, showing that the development of drug resistance could be prevented by limiting the activity of coregulator ...

The Surprising Connection Between Male Infertility and Family Cancer Risk

Apr. 8, 2024 — A study suggests families with infertile male relatives may face elevated cancer risks. Tapping into genetic data, families could help personalize cancer risk ...

Latest Headlines

updated 10:46pm EDT

Microbial Signature of Colorectal Cancer-Associated Mutations Identified in New Study

Apr. 4, 2024 — Researchers have connected KRAS mutations in colorectal cancer to microbial signatures in the ...

Mapping the Evolution of Urinary Tract Cancer Cells

Mar. 18, 2024 — Researchers have performed the most comprehensive analysis to date of cancer of the ureters or the urine-collection cavities in the kidney, known as upper tract urothelial carcinoma (UTUC). The ...

Genetic Signature May Predict Response to Immunotherapy for Non-Small Cell Lung Cancer

Feb. 23, 2024 — A new study identified a set of 140 genes that may help predict enhanced disease-free survival in patients with non-small cell lung cancer (NSCLC) ...

Mechanism of Drug Reactivating Tumor Suppressors

Feb. 21, 2024 — Researchers have revealed the mechanism of the drug valemetostat shown to be effective in treating certain types of cancer by targeting a protein modification (histone methylation) silencing the ...

Newly Discovered Genetic Markers Help Pinpoint Diabetes Risks, Complications

Feb. 19, 2024 — In the largest genome-wide association study to date on Type 2 diabetes, a team of international researchers has located 1,289 genetic markers ...

Sister Cells Uncover Pre-Existing Resistant States in Cancer

Feb. 12, 2024 — In many cancers, such as ovarian cancer, each round of chemotherapy kills the majority of cancer cells, while a small population of them survives through treatment. These cells are typically more ...

Can Hydrogels Help Mend a Broken Heart?

Feb. 12, 2024 — You can mend a broken heart this valentine s day now that researchers invented a new hydrogel that can be used to heal damaged heart tissue and improve cancer ...

Individualized Predictive Model for Multiple Myeloma Treatment

Feb. 9, 2024 — Researchers around the world share results from a novel model that can provide tailored predictions of how individual patients respond to different ...

Gene-Editing Offers Hope for People With Hereditary Disorder

Feb. 2, 2024 — A group of patients with a hereditary disorder have had their lives transformed by a single treatment of a breakthrough gene-editing therapy, according to the lead ...

Retinal Imaging and Genetics Data Used to Predict Future Disease Risk

Jan. 24, 2024 — In a new study, researchers combined OCT retinal imaging, genetics and big data to estimate how likely a person is to develop eye and systemic diseases in the future. They found significant ...

Research Could Unlock More Precise Prognoses and Targeted Treatments for Children With Cancer

Apr. 9, 2024 — Researchers have identified new variations in neuroblastoma that could lead to a more accurate prognosis and better-targeted treatments for this devastating childhood cancer. A study reveals three ...

Early Identification of Persistent Pain Plus Holistic Interventions Cut Opioid Use

Mar. 20, 2024 — In a new study, researchers found that a carefully worded, short questionnaire successfully identified people who were most likely to develop chronic pain. These patients were then steered to a more ...

Could Two Drugs Be Better Than One for Treating Prostate Cancer?

Jan. 23, 2024 — Combining testosterone-blocking drugs in patients with prostate cancer relapse prevents the spread of cancer better than treatment with a single drug, a multi-institution, Phase 3 clinical trial has ...

Long-Term Follow Up Pinpoints Side Effects of Treatments for Prostate Cancer Patients

Jan. 23, 2024 — A 10-year follow up study of nearly 2,500 U.S. men who received prostate cancer treatment will help inform decision making in terms of treatments and side effects for a diverse ...

Health Researchers Develop Software to Predict Diseases

Jan. 23, 2024 — IntelliGenes analyzes genomic data to discover biomarkers associated with health ...

Genetic Discovery Reveals Who Can Benefit from Preterm Birth Therapy

Jan. 23, 2024 — A new study has identified genetic variants that predict whether patients will respond to treatment for preterm birth, a condition that affects one in 10 infants born in the United ...

AI Harnesses Tumor Genetics to Predict Treatment Response

Jan. 18, 2024 — Cancer resists treatment in a multitude of ways, but a new algorithm developed can decode them all ...

Researchers Identify Key Characteristics Associated With Improved CAR T Outcomes in Large B Cell Lymphoma

Jan. 17, 2024 — Axi-cel CAR T targets the CD19 molecule on large B-cell lymphoma cells. The ZUMA-7 trial demonstrated that axi-cel reduced the risk of disease progression, the need for new therapy, or death by 60% ...

Study Demonstrates Benefit of Precision Medicine Based on Race/ethnicity

Jan. 17, 2024 — A new study highlights racial disparities in a subset of cancer patients and, using advanced biomedical research technology, provides evidence for those differences at the molecular ...

Quest for Personalized Medicine Hits a Snag

Jan. 11, 2024 — The quest for personalized medicine, a medical approach in which practitioners use a patient's unique genetic profile to tailor individual treatment, has emerged as a critical goal in the health ...

Unlocking the Human Genome: Innovative Machine Learning Tool Predicts Functional Consequences of Genetic Variants

Dec. 14, 2023 — In a novel study, researchers introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants across the genome. Unlike current methods that ...

Brain Boost: Can a Coach Help Elders at Risk for Alzheimer's?

Nov. 27, 2023 — As more medications move towards federal approval for Alzheimer's disease, a new study has found that personalized health and lifestyle changes can delay or even prevent memory loss for ...

Personalized Cancer Medicine: Humans Make Better Treatment Decisions Than AI

Nov. 20, 2023 — Treating cancer is becoming increasingly complex, but also offers more and more possibilities. After all, the better a tumor's biology and genetic features are understood, the more treatment ...

Genomic Tug of War Could Boost Cancer Therapy

Nov. 16, 2023 — Researchers have discovered a 'genomic tug of war' in animal studies that could influence how well certain patients -- or certain cancers -- respond to decitabine, a drug used to treat ...

Appropriate Statin Prescriptions Increase Sixfold With Automated Referrals

Nov. 13, 2023 — The odds of prescribing the appropriate dose of statins -- a medicine used to lower 'bad' cholesterol levels -- increased sixfold when automated referrals were made to pharmacy services, ...

Drug Screen Points Toward Novel Diabetes Treatments

Nov. 9, 2023 — A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 ...

187 New Genetic Variants Linked to Prostate Cancer Found in Largest, Most Diverse Study of Its Kind

Nov. 9, 2023 — A globe-spanning scientific team has compiled the most comprehensive list of genetic variants associated with prostate cancer risk -- 451 in all -- through a whole-genome analysis that ranks as the ...

Previous Genetic Association Studies Involving People With European Ancestry May Be Inaccurate

Nov. 7, 2023 — Researchers have found that previous studies analyzing the genomes of people with European ancestry may have reported inaccurate results by not fully accounting for population structure. By ...

Artificial Intelligence May Help Predict -- Possibly Prevent -- Sudden Cardiac Death

Nov. 6, 2023 — Predicting sudden cardiac death may be possible using artificial intelligence (AI) to analyze medical information in electronic health records, according to preliminary research. Researchers analyzed ...

New Methods for Effective Transport of Large Genes in Gene Therapy

Oct. 24, 2023 — One problem in gene therapy is that not all genes transfer equally well into the target cells. Researchers have now developed a flexible method to transfer large genes efficiently and without ...