Pancreatic Cancer News

April 16, 2024

Top Headlines

Opening a New Front Against Pancreatic Cancer

Apr. 8, 2024 — A new type of investigational therapeutic for pancreatic cancer has shown unprecedented tumor-fighting abilities in preclinical models of the ...

A Smart Molecule Beats the Mutation Behind Most Pancreatic Cancer

Mar. 5, 2024 — Researchers have designed a candidate drug that could help make pancreatic cancer, which is almost always fatal, a treatable, perhaps even curable, ...

Pancreatic Cancer Lives on Mucus

Feb. 28, 2024 — Our bodies depend on mucus to function properly. As it turns out, so do some cancer cells. Scientists discovered mucus not only allows young pancreatic cancer cells to grow, but also prevents them from transforming into deadlier, drug-resistant ...

Feb. 20, 2024 — Older people may be at greater risk of developing pancreatic cancer and have poorer prognoses because of age-related changes in cells in the pancreas called fibroblasts, according to new ...

Latest Headlines

updated 3:42pm EDT

Scientists Uncover Key Resistance Mechanism to Wnt Inhibitors in Pancreatic and Colorectal Cancers

Apr. 11, 2024 — A new study reveals why some pancreatic and colorectal tumors resist targeted anti-Wnt drugs and suggests how to overcome it, offering new hope to ...

Study Finds Less Invasive, Safer Option for Removing Benign Pancreatic Tumors

Apr. 4, 2024 — Researchers describe a new technique for the minimally invasive removal of benign tumors located in the challenging posterior head of the pancreas ...

Pancreatic Cancer Hijacks a Brain-Building Protein

Feb. 14, 2024 — Scientists have discovered that pancreatic ductal adenocarcinoma (PDAC) hijacks a protein called EN-1 to evade cancer-fighting genes during metastasis. Future drugs targeting EN-1 or related proteins ...

Study Suggests That Unintentional Weight Loss Is a Signal to See a Doctor

Jan. 23, 2024 — Unintentional weight loss is associated with an increase in the risk of a cancer diagnosis within the coming year, according to a new study. Compared with participants who did not lose weight, recent ...

Targeting Annexin-A1 Can Halt Cancer Cell Growth

Jan. 19, 2024 — A new study highlights the effectiveness of MDX-124, the first therapeutic drug to target annexin-A1, a protein which is overexpressed in several cancer types and promotes tumor ...

Deregulation of Alternative RNA Splicing Promotes Pancreatic Cancer Progression and Metastasis

Jan. 13, 2024 — In a new study, researchers demonstrate that deregulation of a protein called RBFOX2, involved in RNA splicing, contributes to the progression and ...

Scientists Use Organoid Model to Identify Potential New Pancreatic Cancer Treatment

Dec. 27, 2023 — A drug screening system that models cancers using lab-grown tissues called organoids has helped uncover a promising target for future pancreatic ...

Novel and Promising Pancreatic Cancer Organoids for Effective Screening of Anticancer Drugs

Dec. 7, 2023 — The treatment of pancreatic cancer, an aggressive form of cancer associated with high mortality rates, is challenging owing to limited options and ...

How Drugs Can Target the Thick 'Scar Tissue' of Pancreatic Cancer

Dec. 6, 2023 — Researchers discovered how anti-cancer drugs called HDAC inhibitors help treat pancreatic cancer by altering scar tissue (fibroblast) development. The findings suggest HDAC inhibitors could be ...

Stimulating Nerves Connected to the Pancreas Regenerates Insulin-Producing Cells, Mouse Study Shows

Dec. 4, 2023 — Decreasing pancreatic beta cell numbers -- the only cells that produce insulin -- is a leading cause of diabetes. In a promising development, a ...

Promising Anticancer Drug Targeting KRAS Protein

Dec. 18, 2023 — A team of scientists has successfully developed a groundbreaking targeted therapy that hones in on the KRAS protein that drives some of the deadliest human cancers, including pancreatic, lung and ...

Macrophages 'Eat' Insulin-Producing Cells to Regulate Insulin After Mice Have Given Birth

Dec. 4, 2023 — Pregnancy brings a rise in pancreatic beta cells -- the cells that produce insulin. Shortly after birth, these cells return to their normal levels. The mechanisms behind this process had remained a ...

Can We Crack This Cancer's Immune Response?

Nov. 29, 2023 — Researchers have discovered antibodies that interact with pancreatic cancer cells and healthy cells. These findings contribute to our knowledge of how the disease works. And they could help pinpoint ...

Novel Molecular Mechanisms in the Early Development of Diabetes Mellitus

Nov. 21, 2023 — Researchers conducted a gene expression analysis at the single-cell level on pancreatic islets from prediabetic and diabetic mouse models. Analysis results revealed upregulation ...

Pancreatic Cancer Discovery Opens the Door for New Clinical Trial

Nov. 16, 2023 — A new scientific finding is the foundation for the first clinical trial in the U.S. to study an experimental drug's ability to fight pancreatic cancer with metastasis to the liver. ...

Nanoparticles for Optimized Cancer Therapy

Nov. 15, 2023 — Pancreatic cancer is one of the deadliest types of cancers in humans. It is the fourth leading cause of cancer-related deaths in the western world. The early stages of the disease often progress ...

Drug Screen Points Toward Novel Diabetes Treatments

Nov. 9, 2023 — A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 ...

A Step Closer to Injection-Free Diabetes Care: Innovation in Insulin-Producing Cells

Nov. 6, 2023 — A team has developed a new step to improve the process for creating insulin-producing pancreatic cells from a patient's own stem cells, bringing the prospect of injection-free treatment closer ...

High Insulin Levels Directly Linked to Pancreatic Cancer

Oct. 31, 2023 — The first detailed explanation of why people with obesity and Type 2 diabetes are at an increased risk of pancreatic cancer has been published. The research demonstrates that excessive insulin levels ...

New Study Suggests Promising Approach for Treating Pancreatic Cancer

Oct. 18, 2023 — A new study carried out in mice, has identified cells that drive the spread of pancreatic cancer and discovered a weakness in these cells that could be targeted using existing drugs. This offers a ...

A Powerful New Tool in the Fight Against One of the Deadliest Cancers

Oct. 16, 2023 — A research team has developed a theranostics approach to both diagnose and treat certain pancreatic cancer cases. They radioactively labeled a monoclonal antibody targeting glypican-1, which is ...

Can Immunity from Routine Vaccines Be Used to Fight Cancer?

Oct. 10, 2023 — A team has demonstrated in theory that a protein antigen from a childhood vaccine can be delivered into the cells of a malignant tumor to refocus the body's immune system against the cancer, ...

Newfound Mechanism Suggests Drug Combination Could Starve Pancreatic Cancer

Oct. 9, 2023 — A study found that a new combination of treatments safely decreased growth of pancreatic cancer in mice by preventing cancer cells from scavenging for ...

'Super-Enhancer' Super-Charges Pancreatic Tumor Growth

Sep. 6, 2023 — Scientists identified new set of molecules that drive the growth of human pancreatic cancer cell lines, explaining how genetic mutations can activate genetic 'super-enhancers' that promote ...

Drug That Targets Scar-Like Tissue in Tumors Shows Promise for Aggressive Pancreatic Cancer

Aug. 29, 2023 — Early laboratory results in mice show the drug PXS-5505 increases survival when combined with chemotherapy in the treatment of pancreatic ductal ...

Enhanced Tumor Modeling Using Laponite Bioinks for 3D Bioprinting

Aug. 3, 2023 — Scientists have developed a nanoengineered bioink with improved bonding and cross-linking capabilities for 3D bioprinted tumor models. These capabilities are enabled by the addition of Laponite, ...

New Research Casts Doubt on Role of Fungus in Driving Pancreatic Cancer

Aug. 3, 2023 — Four years ago, a report that a common species of fungus might fuel pancreatic cancer offered a promising new view of the deadly disease. But in working to validate the finding, researchers have ...

Pancreatic Cancer Vaccine Plus Immunotherapy and Antibody Spark Immune System Response in Pancreatic Cancers

July 17, 2023 — Giving patients with operable pancreatic cancers a three-pronged combination immunotherapy treatment consisting of the pancreatic cancer vaccine GVAX, the immune checkpoint therapy nivolumab and ...

One-Two Punch: Novel Drug Pairing Could Beat Pancreatic Cancer

June 28, 2023 — Researchers find a combination of drugs outperformed other treatments in human and mouse models of pancreatic cancer; now urge clinical ...

Cancer Cells Use a New Fuel in Absence of Sugar

May 18, 2023 — Researchers have discovered a new nutrient source that pancreatic cancer cells use to grow. The molecule, uridine, offers insight into both biochemical processes and possible therapeutic pathways. ...