Brain Tumor News

March 31, 2025

Top Headlines

Mar. 25, 2025 — Scientists have discovered a promising way to trigger immune responses against certain tumors, using a lupus-related antibody that can slip, undetected, into 'cold' tumors and flip on an immune response that has been turned off by cancer. The ...

Classifying Childhood Brain Cancers by Immune Response May Improve Diagnostics and Treatments

Mar. 19, 2025 — The new approach establishes an opportunity to harness the success of immunotherapies that revolutionized the treatment of childhood leukemias for childhood brain ...

Re-Purposed FDA-Approved Drug Could Help Treat High-Grade Glioma

Mar. 13, 2025 — A study shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United States Food and Drug Administration to treat gastrointestinal stromal tumors ...

Genetic Mutations Linked to Toxin Exposure Found in Firefighters' Brain Tumors

Mar. 10, 2025 — In a study comparing the glioma tumors of firefighters and non-fighters, researchers found a mutational signature tied to exposure to haloalkanes, which are used in flame retardants, fire ...

Latest Headlines

updated 8:46pm EDT

Promising Target in Brain Cancer

Feb. 28, 2025 — Scientists have discovered a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells from fighting cancer to enabling further tumor ...

Treatment Strategy Reprograms Brain Cancer Cells, Halting Tumor Growth

Feb. 26, 2025 — Scientists have identified a potential new strategy for treating glioblastoma, the deadliest form of brain cancer, by reprogramming aggressive cancer cells into harmless ...

Why Brain Cancer Is Often Resistant to Immunotherapy

Feb. 26, 2025 — New findings could help make immunotherapies for brain cancer more effective. The team analyzed almost 200,000 individual immune cells in tumor samples taken from patients with glioma, the most ...

Study Reveals Activity of Navtemadlin in Glioblastoma, Points to Possible Treatment Improvements

Feb. 19, 2025 — Clinical research suggests that combining a novel agent called navtemadlin with DNA-damaging chemotherapy for the treatment of glioblastoma, a form ...

Nerves Electrify Stomach Cancer, Sparking Growth and Spread

Feb. 19, 2025 — Researchers have found that a cancer outside the brain makes electrical connections with the nervous system to fuel cancer growth and aid its ...

Jumbled Proteins Paint a Bold Target on the Backs of Brain Tumors

Feb. 19, 2025 — Immune therapy has transformed how cancer is treated, but many tumors continue to evade these treatments, thanks to their resemblance to healthy ...

New Perspectives for Personalized Therapy of Brain Tumors

Feb. 11, 2025 — Scientists have developed an innovative method for growing brain tumors of individual patients in the laboratory that mimic the original structure and the molecular property of the parental tumor as ...

Co-Located Cell Types Help Drive Aggressive Brain Tumors

Feb. 7, 2025 — A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, according to new ...

Breakthrough in Childhood Brain Cancer Research Could Heal Treatment-Resistant Tumors, Keep Them in Remission

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in ...

Research Discovery Halts Childhood Brain Tumor Before It Forms

Feb. 4, 2025 — A research team has identified a critical event driving tumor growth in a type of medulloblastoma -- and a way to block ...

Routine Brain MRI Screening in Asymptomatic Late Stage Breast Cancer Patients

Jan. 28, 2025 — A new study shows that asymptomatic brain metastasis is more common in stage 4 breast cancer patients than previously believed. The study suggests that doctors may need to rethink current screening ...

AI Innovation Unlocks Non-Surgical Way to Detect Brain Cancer Spread

Jan. 14, 2025 — Researchers have developed an artificial intelligence (AI) model to detect the spread of metastatic brain cancer using MRI scans, offering insights into patients' cancer without aggressive ...

Route of Entry for Semliki Forest Virus Into the Brain Revealed

Jan. 13, 2025 — Semliki Forest virus was originally isolated from mosquitoes in the Semliki Forest, Uganda, hence the name. Upon systemic infection from mosquito bites, Semliki Forest virus causes mild blood viremia ...

Tumor-Secreted Protein May Hold the Key to Better Treatments for Deadly Brain Tumor

Jan. 8, 2025 — A study has found targeting a protein called endocan and its related signaling pathway could be a promising new approach for treating glioblastoma, an aggressive and lethal type of brain ...

Breakthrough in Treatment Approach Showing Promise in the Fight Against Glioblastoma

Dec. 16, 2024 — Medical researchers have announced the results of an innovative treatment approach that may offer improvement in overall survival in older patients with newly diagnosed glioblastoma while maintaining ...

Brain Tumor Organoids Accurately Model Patient Response to CAR T Cell Therapy

Dec. 9, 2024 — Researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient's response to CAR T cell therapy in real time. The organoid's ...

Molecular Zip Code Draws Killer T Cells Straight to Brain Tumors

Dec. 5, 2024 — Scientists have developed a 'molecular GPS' to guide immune cells into the brain and kill tumors without harming healthy ...

Researchers Design Novel Immunotherapy for Brain Cancer

Dec. 3, 2024 — Scientists created a new therapeutic design for glioblastoma, the deadliest form of brain cancer. The lab engineered molecules called trispecifics that connect cancer-killing T cells with not just ...

Glioblastoma: New Treatment Attacks Brain Tumors from Multiple Angles

Nov. 12, 2024 — Glioblastoma is the most common kind of malignant brain tumor in adults. So far, no treatment has been able to make this aggressive tumor permanently disappear. The tumor cells are too varied, and ...

Researchers Make Glioblastoma Cells Visible to Attacking Immune Cells

Nov. 7, 2024 — Researchers have identified a possible way to make glioblastoma cells vulnerable to different types of immunotherapy. The strategy, which they demonstrated in cells in the lab, forces brain cancer ...

Researchers Home in on Tumor Vulnerabilities to Improve Odds of Treating Glioblastoma

Nov. 4, 2024 — Researchers have uncovered new targets that could be the key to effectively treating glioblastoma, a lethal type of brain cancer. These targets were identified through a screen for genetic ...

Repurposing Drug Shows Promise in Fighting Aggressive Brain Tumors

Oct. 17, 2024 — Research provides evidence that a drug used to slow the progression of the disease ALS shows promise in suppressing the self-renewing cancerous stem cells that challenge the present standards of care ...

Study Explores Novel Therapeutic Treatment for Glioblastoma

Oct. 7, 2024 — Researchers discovered combining the brain-penetrating antipsychotic drug pimozide with a clinically investigative glutamine metabolism inhibitor, CB-839, can overcome tumor resistance and ...

Antidepressant Shows Promise for Treating Brain Tumors

Sep. 20, 2024 — Researchers have used a drug screening platform they developed to show that an antidepressant, currently on the market, kills tumor cells in the dreaded glioblastoma -- at least in the cell-culture ...

Antibody-Drug Conjugate Found Effective Against Brain Metastases in Patients With HER2-Positive Breast Cancer

Sep. 13, 2024 — A drug that delivers chemotherapy directly to tumors has shown impressive activity against some of the hardest-to-reach cancer cells: those that have spread to the brain in patients with advanced ...

How the Scars of Demolished Brain Tumors Seed Relapse

Sep. 9, 2024 — A study has discovered that recurrent tumors of the aggressive brain cancer glioblastoma multiforme (GBM) grow out of the fibrous scars of malignant predecessors destroyed by interventions such as ...

Human Brain Cancers Fire Electrical Impulses -- Researchers Reveal Unexpected Hybrid Cell Spiking the Signals

Sep. 5, 2024 — Researcher have uncovered a new cell type in the human brain that fires electrical impulses. The cells are hybrids, part neuron and part glia, and are present in both glioma, a type of brain tumor, ...

Adolescent Glioma Subtype Responds to CDK4/6 Inhibitor

Sep. 3, 2024 — Researchers took a deep look at tumor samples from patients with diffuse hemispheric glioma and discovered an unexpected vulnerability to CDK4/6 ...

New Study Uncovers Key Mechanisms Responsible for the Transformation of Adult Progenitors Into Brain Tumors

Sep. 3, 2024 — A new study sheds light on why certain oligodendrocyte progenitor cells (OPCs) in the adult brain transform into gliomas, the most common and incurable type of adult brain ...

NK Cells Expressing Interleukin-21 Show Promising Antitumor Activity in Glioblastoma Cells

Aug. 12, 2024 — Natural killer (NK) cells engineered to express interleukin-21 (IL-21) demonstrated sustained antitumor activity against glioblastoma stem cell-like cells (GSCs) both in vitro and in vivo, according ...