Leukemia News

December 23, 2024

Top Headlines

Blood Test Could Make Cancer Treatments Safer and More Effective

Dec. 16, 2024 — Scientists have developed a new blood test that could screen cancer patients to help make their treatment safer and more ...

New Drug Tested to Reduce Side Effect of 'Half-Matched' Stem Cell Transplants

Dec. 5, 2024 — Stem cell transplantation is used to treat several types of blood cancers, but carries the risk of a life-threatening side effect called graft-versus-host disease. Results from a clinical trial ...

Changes in Blood Cell Production Over the Lifetime Could Impact Leukemia Outcomes

Dec. 5, 2024 — The first comprehensive map of the dramatic changes that take place in the blood system over the course of the human lifetime could have implications for the treatment of acute myeloid leukemia and ...

How Breast Cancer Cells Survive in Bone Marrow After Remission

Dec. 4, 2024 — A new study has shed light on a previously poorly understood aspect of breast cancer recurrence: how cancer cells survive in bone marrow despite targeted ...

Latest Headlines

updated 10:20pm EST

The Most Extensive Epigenetic Database of Malignant Blood Cells Created

Nov. 26, 2024 — Researchers published a dataset covering thousands of methylated sites from hundreds of cancer-derived cultured cells, covering many leukemias, lymphomas and myelomas, from humans and mice. With this ...

Chromosomal Chaos Promotes Therapy Resistance in Leukemia Cells and Opens Up New Treatment Approaches

Nov. 25, 2024 — Chromosomal instability plays a crucial role in the progression of cancer: it shapes the properties of tumor cells and drives the development of ...

Groundbreaking Research Unlocks Precision Therapy for Drug-Resistant Leukaemia

Nov. 8, 2024 — Scientists investigated how an inherited genetic variation common among East Asians contributes to drug resistance in cancer cells, driving more ...

Cellular Couriers: Body's 'Delivery Trucks' Could Lead to New Cancer Blood Test

Oct. 28, 2024 — Researchers have found a potential new diagnostic marker that could be used to better detect the level of tissue damage in our ...

Why Breast Cancer Spreads to Bone

Oct. 18, 2024 — Researchers have developed an in vitro cancer model to investigate why breast cancer spreads to bone. Their findings hold promise for advancing the development of preclinical tools to predict breast ...

Rapid Blood Cancer Diagnostic Could Speed Decisions and Save Lives

Oct. 9, 2024 — Researchers have created a CRISPR-based rapid molecular diagnostic for two forms of leukemia that are driven by mutations that involve gene fusions. The technology accurately detects the presence of ...

Promising Cell Therapy Offers Hope for Relapsed or Refractory T-Cell Leukaemia

Oct. 7, 2024 — Fratricide-resistant CD7 CAR-T therapy by NUS proves effective in treating relapsed or refractory T-cell ...

Radon, Even at Levels Below EPA Guideline for Mitigation, Is Linked to Childhood Leukemia

Sep. 30, 2024 — A study of more than 700 counties across multiple U.S. states found a link between childhood leukemia and levels of decaying radon gas, including ...

Why Children With Down Syndrome Have Higher Risk of Leukemia

Sep. 25, 2024 — People with Down syndrome face a higher risk of developing leukemia. Now researchers explain why, by identifying specific changes in blood cells of people with Down ...

Triplet Regimen Yields Promising Response in Advanced-Phase Chronic Myeloid Leukemia

Sep. 17, 2024 — According to new research, 80% of patients with previously untreated or relapsed/refractory advanced-phase chronic myeloid leukemia (CML) -- ...

Tumor-Induced B Cell Changes Reveal Potential Biomarker for Treatment Response in Triple Negative Breast Cancer

Sep. 12, 2024 — Researchers have discovered new insights into tumor-induced B cell changes in blood and bone marrow of triple negative breast cancer patients. The findings show two distinct patterns of B cell ...

Blood Stem Cell Breakthrough Could Transform Bone Marrow Transplants

Sep. 3, 2024 — Researchers have made a world first breakthrough into creating blood stem cells that closely resemble those in the human body. And the discovery could soon lead to personalized treatments for ...

P-Bodies Sustain Acute Myeloid Leukemia

Aug. 21, 2024 — An international team of scientists has uncovered a mechanism by which acute myeloid leukemia (AML) cells sustain their growth. AML cells prevent the synthesis of proteins that suppress their growth ...

Scientists Identify Genes Linked to Relapse in the Most Common Form of Childhood Leukemia

Aug. 12, 2024 — Scientists have identified novel genetic variations that influence relapse risk in children with standard risk B-cell acute lymphoblastic leukemia (SR B-ALL), the most common childhood ...

Potential New Approach to Enhancing Stem-Cell Transplants

Aug. 9, 2024 — A discovery may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the ...

Improved Chemokine Homing Enhances CAR T--Cell Therapy for Osteosarcoma

Aug. 5, 2024 — Investigators identified a chemokine/chemokine receptor mismatch for osteosarcoma (i.e., osteosarcomas secrete chemokines for which CAR T cells do not express receptors). The researchers modified CAR ...

Surprising Finding in Glioblastomas

July 31, 2024 — Glioblastomas are highly aggressive, usually incurable brain tumors. If all therapeutic options are exhausted, patients have an average life expectancy of less than two years. Now researchers have ...

Fighting Leukemia by Targeting Its Stem Cells

July 24, 2024 — Acute myeloid leukemia is one of the deadliest cancers. Leukemic stem cells responsible for the disease are highly resistant to treatment. A team has made a breakthrough by identifying some of the ...

Trial of Cell-Based Therapy for High-Risk Lymphoma Leads to FDA Breakthrough Designation

July 10, 2024 — CAR-T cell therapy helps some with intractable lymphoma, but those who relapse have few options. Modifying the therapy's molecular target improved ...

Age Is Just a Number: Immune Cell 'Epigenetic Clock' Ticks Independently of Organism Lifespan

June 12, 2024 — Researchers use epigenetic clock, DNA methylation and mouse model to demonstrate that T cell proliferation can stretch past organism lifespan and acuta lymphoblastic leukemia T cells appear hundreds ...

Anti-Diabetic Treatment Associated With Reduced Risk of Developing Blood Cancer

May 17, 2024 — People who use metformin are less likely to develop a myeloproliferative neoplasm (MPN) over time, indicating that the treatment may help prevent the development of certain types of cancers, ...

Derivatives of the Thalidomide Compound Drive Resistant Cancer Cells to Their Deaths

May 13, 2024 — A study points to the possibility that thalidomide derivatives are potentially suitable for treating cancer. Thalidomide was marketed in the 1950s as a sleeping pill. It later gained sad notoriety ...

New Target for Potential Leukemia Therapy

May 8, 2024 — Investigators discovered that a subset of myeloid and lymphoid leukemias depend on a molecular complex called PI3Kgamma for survival. The study provides both mechanistic and preclinical evidence ...

Targeting RAS Proteins May Prevent Relapse in Acute Myeloid Leukemia

Apr. 9, 2024 — Relapses in a common form of leukemia may be preventable following new research that has identified how the cancer develops resistance to first line ...

Targeting Vulnerability in B-Cell Development Leads to Novel Drug Combination for Leukemia

Apr. 8, 2024 — Scientists discovered which tumor cells resist treatment and why. By characterizing B-cells' developmental stages, they designed and tested a drug combination to effectively treat resistant ...

Promising Drug Combination for Multiple Myeloma Treatment

Mar. 25, 2024 — New research has found that venetoclax, a medication currently approved for leukemia, has benefits for patients with multiple myeloma when used in combination with another drug. This discovery offers ...

An Immunotherapy to Overcome Resistant Leukemia

Mar. 21, 2024 — Researchers have discovered that a specific mutation in the cancer cells of an aggressive type of blood cancer can prevent novel immunotherapies such as CAR T-cell therapy from working. Their study ...

Skeleton-Wide Study of Blood Cell Formation Yields Surprising Findings

Mar. 20, 2024 — Imagine being able to count the different types of blood cells being formed inside the tiny bones of a mouse and pinpointing the strings and clusters of cells within the bone marrow that are ...

Clues to Cancer Drug's Deadly Side Effects Could Make It Safer

Feb. 8, 2024 — For some leukemia patients, their only treatment option carries a risk of heart ...

Molecule Can Quickly, and Briefly, Boost White Blood Cell Counts

Jan. 31, 2024 — Treatment with a molecule known as A485 can quickly and temporarily increase levels of white blood cells, a critical part of the body's immune system, an effect that is difficult to deliver with ...