How pre- and postnatal B-12 vitamins improve breast milk vitamin B-12 levels, which supports infant brain development

Pregnant and lactating women are at exceptionally high risk for vitamin B-12 deficiency due to the increased nutritional demands as they provide the micronutrient for themselves and their babies. Many people receive the necessary B-12 the body needs from animal-source foods. However, in countries with low intake of animal-source diets, mother's and infant's deficiency in vitamin B-12 is a serious public health challenge.

In resource-limited settings where maternal undernutrition is pervasive, researchers sought to understand the optimal timing and dosage of B-12 supplements during pregnancy and lactation.

A new study led by Mason Assistant Professor in the College of Public Health Dongqing Wang found that pregnant women who took high doses of oral vitamin B-12 supplements prior to delivery experienced short-term benefits on the levels of B-12 in their breast milk. However, women who took high doses of vitamin B-12 supplements during lactation experienced these benefits for a longer period of time.

"Understanding the impacts of prenatal and postnatal vitamin B-12 supplements on the level of B-12 in breast milk is crucial to design effective nutritional interventions to protect mothers and infants from vitamin B-12 deficiencies," said Wang, who was the principal investigator. "Our findings underscore the importance of prenatal vitamins for short-term benefits in breast milk and postnatal vitamins for more sustained impacts on B-12 adequacy in breast milk; both prenatal and postnatal supplements support healthy growth and development in the baby."

The study also found that the effect of the prenatal vitamin B-12 supplement diminished when used together with the postnatal supplement. Likewise, the effect of the postnatal vitamin B-12 supplement diminished when used together with the prenatal supplement.

"It appears that there was a certain plateau in the effect when prenatal and postnatal supplements were used together," said Wang. "The plateau could mean that either prenatal or postnatal vitamins could correct maternal vitamin B-12 deficiency, but the plateau does not preclude the need for combined prenatal and postnatal supplements through pregnancy and breastfeeding to sustain maternal B-12 levels in populations with high levels of dietary inadequacy."

The research was primarily funded by an Early Career Award from the Thrasher Research Fund.