Phytochemicals In Plant-based Foods Could Help Battle Obesity, Disease

Eating more plant-based foods, which are rich in substances called phytochemicals, seems to prevent oxidative stress in the body, a process associated with obesity and the onset of disease, according to findings published online in advance of the print edition of the Journal of Human Nutrition and Dietetics.

To get enough of these protective phytochemicals, researchers suggest eating plant-based foods such as leafy greens, fruits, vegetables, nuts and legumes at the start of a meal. Using what is known as a phytochemical index, which compares the number of calories consumed from plant-based foods compared with the overall number of daily calories, could also help people make sure they remember to get enough phytochemicals during their regular meals and snacks, said Heather K. Vincent, Ph.D., the lead author of the paper.

"We need to find a way to encourage people to pull back on fat and eat more foods rich in micronutrients and trace minerals from fruits, vegetables, whole grains and soy," said Vincent, an assistant professor in the UF Orthopaedics and Sports Medicine Institute. "Fill your plate with colorful, low-calorie, varied-texture foods derived from plants first. By slowly eating phytochemical-rich foods such as salads with olive oil or fresh-cut fruits before the actual meal, you will likely reduce the overall portion size, fat content and energy intake. In this way, you're ensuring that you get the variety of protective, disease-fighting phytochemicals you need and controlling caloric intake."

The researchers studied a group of 54 young adults, analyzing their dietary patterns over a three-day period, repeating the same measurement eight weeks later. The participants were broken into two groups: normal weight and overweight-obese.

Although the adults in the two groups consumed about the same amount of calories, overweight-obese adults consumed fewer plant-based foods and subsequently fewer protective trace minerals and phytochemicals and more saturated fats. They also had higher levels of oxidative stress and inflammation than their normal-weight peers, Vincent said. These processes are related to the onset of obesity, heart disease, diabetes and joint disease, she added.

"Diets low in plant-based foods affect health over the course of a long period of time," Vincent said. "This is related to annual weight gain, low levels of inflammation and oxidative stress. Those are the onset processes of disease that debilitate people later in life."

Oxidative stress occurs when the body produces too many damaging free radicals and lacks enough antioxidants or phytochemicals to counteract them. Because of excess fat tissue and certain enzymes that are more active in overweight people, being obese can actually trigger the production of more free radicals, too.

Because many phytochemicals have antioxidant properties, they can help combat free radicals, Vincent said. Phytochemicals include substances such as allin from garlic, lycopene from tomatoes, isoflavones from soy, beta carotene from orange squashes and anythocyanins from red wine, among others.

"People who are obese need more fruits, vegetables, legumes and wholesome unrefined grains," she said. "In comparison to a normal-weight person, an obese person is always going to be behind the eight ball because there are so many adverse metabolic processes going on."

Instead of making drastic changes, people could substitute one or two choices a day with phytochemical-rich foods to make a difference in their diets, Vincent said. For example, substituting a cup of steeped plain tea instead of coffee or reaching for an orange instead of a granola bar could increase a person's phytochemical intake for the day without even changing the feeling of fullness. Over time, replacing more pre-packaged snacks with fresh produce or low-sugar grains could become a habit that fights obesity and disease, Vincent said.

"We always want to encourage people to go back to the whole sources of food, the nonprocessed foods if we can help it," Vincent said. "That would be the bottom line for anyone, regardless of age and body size, keep going back to the purer plant-based foods. Remember to eat the good quality food first."

Currently, there are no recommendations for how much of these plant compounds people should be getting each day, says Susanne Talcott, Ph.D., an assistant professor of food science and nutrition at Texas A&M University. Using the phytochemical index could be a good way to come up with these recommendations, she said.

Like Vincent, Talcott also cautions people to try and stick to the whole sources of foods and be wary of processed foods that promise benefits from added plant compounds.

"Consumers should stick with what we have known for decades and eat fresh or frozen fruits and vegetables," she said. "Stick with those kinds of foods rather than reaching out for a tropical wonder pill or juice."