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Retinal therapy may restore lost vision

Date:
April 2, 2025
Source:
The Korea Advanced Institute of Science and Technology (KAIST)
Summary:
Researchers have successfully developed a novel drug to restore vision. The treatment method restores vision through retinal nerve regeneration.
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Vision is one of the most crucial human senses, yet over 300 million people worldwide are at risk of vision loss due to various retinal diseases. While recent advancements in retinal disease treatments have successfully slowed disease progression, no effective therapy has been developed to restore already lost vision -- until now. KAIST researchers have successfully developed a novel drug to restore vision.

KAIST (represented by President Kwang Hyung Lee) announced on the 30th of March that a research team led by Professor Jin Woo Kim from the Department of Biological Sciences has developed a treatment method that restores vision through retinal nerve regeneration.

The research team successfully induced retinal regeneration and vision recovery in a disease-model mouse by administering a compound that blocks the PROX1 (prospero homeobox 1) protein, which suppresses retinal regeneration. Furthermore, the effect lasted for more than six months.

This study marks the first successful induction of long-term neural regeneration in mammalian retinas, offering new hope to patients with degenerative retinal diseases who previously had no treatment options.

As the global population continues to age, the number of retinal disease patients is steadily increasing. However, no treatments exist to restore damaged retinas and vision. The primary reason for this is the mammalian retina's inability to regenerate once damaged.

Studies on cold-blooded animals, such as fish -- known for their robust retinal regeneration -- have shown that retinal injuries trigger Müller glia cells to dedifferentiate into retinal progenitor cells, which then generate new neurons. However, in mammals, this process is impaired, leading to permanent retinal damage.

Through this study, the research team identified the PROX1 protein as a key inhibitor of Müller glia dedifferentiation in mammals. PROX1 is a protein found in neurons of the retina, hippocampus, and spinal cord, where it suppresses neural stem cell proliferation and promotes differentiation into neurons.

The researchers discovered that PROX1 accumulates in damaged mouse retinal Müller glia, but is absent in the highly regenerative Müller glia of fish. Furthermore, they demonstrated that the PROX1 found in Müller glia is not synthesized internally but rather taken up from surrounding neurons, which fail to degrade and instead secrete the protein.

Based on this finding, the team developed a method to restore Müller glia's regenerative ability by eliminating extracellular PROX1 before it reaches these cells.

This approach involves using an antibody that binds to PROX1, developed by Celliaz Inc., a biotech startup founded by Professor Jin Woo Kim's research lab. When administered to disease-model mouse retinas, this antibody significantly promoted neural regeneration. Additionally, when delivered, the antibody gene to the retinas of retinitis pigmentosa disease model mice, it enabled sustained retinal regeneration and vision restoration for over six months.

The retinal regeneration-inducing therapy is currently being developed by Celliaz Inc. for application in various degenerative retinal diseases that currently lack effective treatments. The company aims to begin clinical trials by 2028.

Dr. Eun Jung Lee stated, "We are about completing the optimization of the PROX1-neutralizing antibody (CLZ001) and move to preclinical studies before administering it to retinal disease patients. Our goal is to provide a solution for patients at risk of blindness who currently lack proper treatment options."

This research was supported by research funds from Korean National Research Foundation (NRF) and the Korea Drug Development Foundation (KDDF).


Story Source:

Materials provided by The Korea Advanced Institute of Science and Technology (KAIST). Note: Content may be edited for style and length.


Journal Reference:

  1. Eun Jung Lee, Museong Kim, Sooyeon Park, Ji Hyeon Shim, Hyun-Ju Cho, Jung Ah Park, Kihyun Park, Dongeun Lee, Jeong Hwan Kim, Haeun Jeong, Fumio Matsuzaki, Seon-Young Kim, Jaehoon Kim, Hanseul Yang, Jeong-Soo Lee, Jin Woo Kim. Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer. Nature Communications, 2025; 16 (1) DOI: 10.1038/s41467-025-58290-8

Cite This Page:

The Korea Advanced Institute of Science and Technology (KAIST). "Retinal therapy may restore lost vision." ScienceDaily. ScienceDaily, 2 April 2025. <www.sciencedaily.com/releases/2025/04/250402123041.htm>.
The Korea Advanced Institute of Science and Technology (KAIST). (2025, April 2). Retinal therapy may restore lost vision. ScienceDaily. Retrieved April 3, 2025 from www.sciencedaily.com/releases/2025/04/250402123041.htm
The Korea Advanced Institute of Science and Technology (KAIST). "Retinal therapy may restore lost vision." ScienceDaily. www.sciencedaily.com/releases/2025/04/250402123041.htm (accessed April 3, 2025).

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