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Long-term benefits of weight-loss surgery in young people

Adolescents see a greater remission of type 2 diabetes compared to adults

Date:
October 30, 2024
Source:
NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Summary:
Young people with severe obesity who underwent weight-loss surgery at age 19 or younger continued to see sustained weight loss and resolution of common obesity-related comorbidities 10 years later, according to results from a large clinical study.
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Young people with severe obesity who underwent weight-loss surgery at age 19 or younger continued to see sustained weight loss and resolution of common obesity-related comorbidities 10 years later, according to results from a large clinical study funded by the National Institutes of Health (NIH).

Study participants with an average age of 17 underwent gastric bypass or sleeve gastrectomy weight-loss surgery. After 10 years, participants sustained an average of 20% reduction in body mass index (BMI), 55% reduction of type 2 diabetes, 57% reduction of hypertension, and 54% reduction of abnormal cholesterol. Both gastric bypass and sleeve gastrectomy had similar results.

The 55% reduction in type 2 diabetes was much higher than the rates observed in adults after weight-loss surgery (18% at seven years and 12.7% at 12 years) in a recently published NIH-funded study.

Type 2 diabetes tends to progress more rapidly when it occurs in young people, and these findings demonstrate the greater health benefits and durability of bariatric surgery in youth than would be expected in similarly treated adults.

The study, known as Teen Longitudinal Assessment of Bariatric Surgery (Teen LABS), was supported by NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) through grants DK072493, DK072493, DK095710 and NIH's National Center for Research Resources and the National Center for Advancing Translational Sciences Clinical and Translational Science Awards Program grants TR000077 and TR000114.

Data related to these findings are available for request at the NIDDK Central Repository.


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Materials provided by NIH/National Institute of Diabetes and Digestive and Kidney Diseases. Note: Content may be edited for style and length.


Journal Reference:

  1. Justin R. Ryder, Todd M. Jenkins, Changchun Xie, Anita P. Courcoulas, Carroll M. Harmon, Michael A. Helmrath, Stephanie Sisley, Marc P. Michalsky, Mary Brandt, Thomas H. Inge. Ten-Year Outcomes after Bariatric Surgery in Adolescents. New England Journal of Medicine, 2024; 391 (17): 1656 DOI: 10.1056/NEJMc2404054

Cite This Page:

NIH/National Institute of Diabetes and Digestive and Kidney Diseases. "Long-term benefits of weight-loss surgery in young people." ScienceDaily. ScienceDaily, 30 October 2024. <www.sciencedaily.com/releases/2024/10/241030171914.htm>.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases. (2024, October 30). Long-term benefits of weight-loss surgery in young people. ScienceDaily. Retrieved October 31, 2024 from www.sciencedaily.com/releases/2024/10/241030171914.htm
NIH/National Institute of Diabetes and Digestive and Kidney Diseases. "Long-term benefits of weight-loss surgery in young people." ScienceDaily. www.sciencedaily.com/releases/2024/10/241030171914.htm (accessed October 31, 2024).

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