Discovered new regulation for infant growth

"A better understanding of the biology of infant growth is important as growth-related diseases such as obesity and malnutrition are global societal challenges," says Professor Pål Rasmus Njølstad, Department of Clinical Science, University of Bergen (UiB) who directed the study.

Different BMI-signals for children and adults

It has been assumed that there are more or less the same genes that control BMI development in children and adults.

"We have now found that such genetic signals actually exist, but that the most important are nevertheless different between children and adults and that they vary considerably during childhood," Njølstad says.

The study is the first large-scale genetics study to investigate age-dependent effects in continuous BMI measurements from birth to eight years. It is also the first large-scale genetics study conducted in the Norwegian Mother, Father, and Children Cohort Study (MoBa), which includes 114,000 children and their parents.

Potential target for drug intervention

The study shows a previously unknown and dynamic role of common genetic variants in genes involved in the leptin signaling pathway that affect BMI during fetal, newborn, and infant growth says professor Stefan Johansson who co-led the study.

Leptin is a hormone predominantly made by the adipose tissue regulating the energy balance by reducing appetite, which in turn diminishes fat storage in adipocytes.

"The study suggests that increased levels of leptin's binding partner, the leptin receptor, in infants have a positive effect on weight gain without being linked to overweight in adults. This finding provides a potential target for drug intervention to increase weight in infants who need it," says Pål Rasmus Njølstad.

Facts: Novel Tools for Early Childhood Predisposition to Obesity and Diabetes, the SELECTionPREDISPOSED Study

• The study´s main objectives are to find novel obesity and diabetes susceptibility genes, to uncover genes involved in the regulation of birth weight and childhood growth, to identify new mechanisms for regulation of growth, development of obesity and diabetes, and to identify the genetic cause of congenital growth-related malformations.
• The study was conducted in collaboration with researchers at the Norwegian Institute of Public Health, the Norwegian University of Science and Technology, and the University of Gothenburg.
• It has been supported by, among others. European Research Council ERC, University of Bergen, Bergen Research Foundation, Foundation Kristian Gerhard Jebsen, Research Council of Norway, Health West, Novo Nordisk Foundation, and the Norwegian Diabetes Association.