New pain treatment tested in humans
- Date:
- November 27, 2017
- Source:
- Wiley
- Summary:
- Nerve growth factor signals through receptors of the tropomyosin-related kinase (Trk) family, and research in animals has shown that inhibitors of Trks A, B, and C can reduce pain. Now a new study provides the first demonstration of pain relief in humans using a Trk inhibitor.
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Nerve growth factor signals through receptors of the tropomyosin-related kinase (Trk) family, and research in animals has shown that inhibitors of Trks A, B, and C can reduce pain. Now a new study in the British Journal of Clinical Pharmacology provides the first demonstration of pain relief in humans using a Trk inhibitor.
The inhibitor was compared with pregabalin, ibuprofen, and placebo, in randomized, double blind, cross-over study with 20 participants.
"One striking aspect of this study is the use of a pain challenge model to assess this novel Trk mechanism. By determining the effect of a single dose of the drug in healthy subjects, we were able to provide an early demonstration of analgesia without the need to run a large patient study," said lead author Dr. Peter Loudon, of Pfizer WRD, in the UK. "Furthermore, the use of a range of different pain challenge models has provided some information on the quality of effect, which may help predict the best patient population for future studies."
Journal Reference:
- Peter Loudon, Pieter Siebenga, Donal Gorman, Katrina Gore, Pinky Dua, Guido van Amerongen, Justin L. Hay, Geert Jan Groeneveld, Richard P. Butt. Demonstration of an anti-hyperalgesic effect of a novel pan Trk inhibitor PF-06273340 in a battery of human evoked pain models.. British Journal of Clinical Pharmacology, 2017; DOI: 10.1111/bcp.13448
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