Who's happy? How long we look at happy faces is in our genes

The new research was led by Dr Bhismadev Chakrabarti at the University of Reading and Professor Simon Baron-Cohen at the University of Cambridge. Their earlier research had shown that polymorphisms (naturally occurring mutations) in CNR1 were associated with altered activity within the striatum (a region of the brain involved in emotion and reward behavior) in response to happy faces.

In the new study the researchers analyzed the DNA from 28 adult volunteers and tested (using a "gaze tracker") how long the volunteers looked at eyes and mouths of faces in video clips showing different emotions. The team found variations within two of the four polymorphisms in CNR1 correlated with a longer gaze at happy faces but not with faces showing disgust. Both of these genomic sites involved for happy faces were within part of the DNA which does not code for protein but instead may be involved in regulating protein production.

Dr Chakrabarti commented, "This is the first study to have shown that how much we gaze at faces is influenced by our genetic make-up. If replicated it has profound implications for our understanding of the drive to socialize, and in turn, the atypical use of gaze in autism."

Funding sources: Research grants from the Medical Research Council (UK); Target Autism Genome; the Nancy Lurie Marks Family Foundation; NIHR CLAHRC for Cambridgeshire and Peterborough NHS Foundation Trust, Trinity College, Cambridge.