Getting to the root of the problem: Intensive diabetes treatment reduces gum disease inflammation
- Date:
- September 17, 2024
- Source:
- Osaka University
- Summary:
- A recent study reveals that intensive diabetes treatment can improve periodontal disease inflammation. Researchers found that two weeks of intensive diabetes treatment under hospitalization for patients with type 2 diabetes significantly improved not only blood sugar control but also PISA, an indicator of gum disease inflammation. Furthermore, the improvement in PISA was related to factors such as insulin secretion capacity and the severity of diabetes complications and comorbidities before diabetes treatment. These findings suggest that early intervention in diabetes is crucial for improving gum disease in diabetic patients.
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A recent study reveals that intensive diabetes treatment can improve periodontal disease inflammation. Researchers found that two weeks of intensive diabetes treatment under hospitalization for patients with type 2 diabetes significantly improved not only blood sugar control but also PISA, an indicator of gum disease inflammation. Furthermore, the improvement in PISA was related to factors such as insulin secretion capacity and the severity of diabetes complications and comorbidities before diabetes treatment. These findings suggest that early intervention in diabetes is crucial for improving gum disease in diabetic patients.
While the link between diabetes and periodontal disease is known, the impact of diabetes treatment on periodontal health is less well understood. Recent research published in Diabetes, Obesity and Metabolism demonstrates that periodontal inflammation can be positively affected just by receiving intensive diabetes treatment.
It is widely believed that there is an interrelationship between diabetes and periodontal disease. While it has been shown that treatment of periodontal disease improves blood glucose control, the effect of diabetes treatment on periodontal disease has remained largely unknown.
A collaborative research team between the Graduate Schools of Dentistry, Medicine, and Engineering at Osaka University administered a two-week intensive diabetes treatment to 29 type 2 diabetes patients, analyzing systemic, and dental indicators before and after treatment. No dental interventions were performed as part of this study; patients only received diabetes treatment. Results showed improvements in both glycoalbumin, a marker of blood sugar control, and PISA (Periodontal Inflamed Surface Area), indicating reduced blood glucose level and periodontal inflammation. Further, comparison of subjects based on PISA improvement revealed that those with significant improvement had higher pre-treatment C-peptide levels, suggesting better insulin secretion and better CVRR and ABI values, indicating less severe diabetic neuropathy and peripheral vascular disorders.
"These research findings are expected to advance our understanding of the mechanisms underlying the relationship between diabetes and periodontal disease," says senior author Masae Kuboniwa. "This study demonstrates that improving periodontal disease in diabetic patients requires not only periodontal treatment but also early diabetes management. We anticipate that promoting collaboration between medical and dental care from the early stages of diabetes can significantly contribute to preventing the onset and progression of periodontal disease in diabetic patients."
Story Source:
Materials provided by Osaka University. Note: Content may be edited for style and length.
Journal Reference:
- Moe Inoue, Akito Sakanaka, Naoto Katakami, Masahiro Furuno, Hitoshi Nishizawa, Kazuo Omori, Naohiro Taya, Asuka Ishikawa, Shota Mayumi, Emiko Tanaka Isomura, Hiroki Takeuchi, Atsuo Amano, Iichiro Shimomura, Eiichiro Fukusaki, Masae Kuboniwa. Periodontal tissue susceptibility to glycaemic control in type 2 diabetes. Diabetes, Obesity and Metabolism, 2024; 26 (10): 4684 DOI: 10.1111/dom.15835
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