Genes responsible for loss of lung function identified

Researchers from Boston University School of Medicine (BUSM) have identified a panel of genes that are active in smokers and ex-smokers who experience faster loss of lung function over time. They believe these genes could be useful to predict which people are most at risk for smoking-related decline in lung function.

"Our discovery that airway genes change before a rapid decline in lung function should give patients with COPD a lot of hope. A test like this could help doctors identify people at risk for COPD before they get it, and help scientists find new treatments to stop the disease before it gets worse," explained corresponding author Katrina Steiling, MD, MSc, assistant professor of medicine at BUSM.

Smoking, and diseases related to smoking, create changes throughout the airways and lungs. These changes can be detected using a procedure called a bronchoscopy, where a small flexible camera inserted through the nose or mouth is used to collect cells with brushes from the sides of the airways. The researchers tested airway brushings from 134 people who were current or former smokers. They found changes in the activity of specific genes in the people that went on to have more rapid worsening of their lung function several years after that initial airway brushing. Some of the genes were more active in the people who rapidly lost lung function while other genes were less active in these people.

According to the researchers, further study of these genes may provide clues as to what causes rapid lung function decline which could be used to develop to new treatments for preventing the development of COPD. "Being able to identify people most at risk for worsening lung function might also make clinical trials of COPD fighting medications easier, by enriching the trials testing new medications for people most likely to benefit from them," added co-author Beth Becker, PhD, a recent graduate from BU's bioinformatics program.

This study further shows another use for the 'airway field of injury' hypothesis. "Cigarette smoking causes changes to the cells in the lungs and airways. Because the changes in the airways are similar to those that occur deep inside the lung, testing the cells in the airways can be used to detect diseases deep within the lungs," added Marc Lenburg, PhD, professor of medicine and pathology and laboratory medicine at BUSM.

These findings appear online in the journal Thorax.

Funding for this study was provided by the National Institutes of Health/National Heart, Lung, and Blood Institute (ROI HL095388 and ROI HL 118542-01) and Dutch Longfonds Foundation (4.2.16.132JO).