Neighborhood features and one's genetic makeup interact to affect cognitive function

Researchers from Florida Atlantic University and collaborators conducted one of the first known studies to examine how cognitive functioning is affected differently by the neighborhood environment depending on one's apolipoprotein E (APOE) genotype -- a genetic risk factor for Alzheimer's disease (AD). For the study, researchers categorized 4,716 participants from the Multi-Ethnic Study of Atherosclerosis as carriers of APOEε2 (lower AD risk), APOEε4 (higher AD risk), and APOEε3, the most common variant, which is considered to have neutral risk for developing AD.

Results of the study, published in the journal Health & Place ,suggest that the cognitive benefits of living in neighborhoods with greater access to social, walking and retail destinations may be limited to individuals with a reduced genetic risk for cognitive decline, specifically APOE ε2 carriers.

"The positive influence of neighborhood environments on cognition may be strongest among individuals who are at the lowest risk for Alzheimer's disease," said Lilah M. Besser, Ph.D., M.S.P.H., senior author who led the study, an assistant professor in FAU's School of Urban and Regional Planning within the College for Social Design and Inquiry, a member of the FAU Brain Institute (I-BRAIN) and a faculty fellow of FAU's Institute for Human Health and Disease Intervention (I-HEALTH). "The risk of cognitive decline among APOE ε4 carriers may be difficult to overcome even when living in beneficial neighborhood environments."

AD is the sixth leading cause of death in the United States and more than 5.8 million Americans are living with the disease. By 2050, this number is projected to rise to nearly 14 million. According to the Alzheimer's Association, in 2019, AD and other dementias cost the nation $290 billion. By 2050, these costs could rise as high as $1.1 trillion.

"Research on the potential influences of the neighborhood environment on cognition and brain aging can help inform recommendations for neighborhood improvements to simultaneously address population growth and healthy brain aging," said Besser. "Knowledge of how the neighborhood environment may affect cognition differentially depending on one's genetic makeup will be important to inform such recommendations."

Study co-authors are James E. Galvin, M.D., M.P.H.; Daniel A. Rodriguez, Ph.D., University of California, Berkley; Teresa Seaman, Ph.D., University of California, Los Angeles; Walter A. Kukull, Ph.D., University of Washington; Stephen R. Rapp, Ph.D., Wake Forest School of Medicine; and Jennifer Smith, Ph.D., M.P.H., University of Michigan.

This work was supported by funding from the Robert Wood Johnson Foundation Active Living Research Program and the National Institutes of Health (NHLBI grant R01HL071759).