Just add heat to open this tiny box

"Imagine mixing two liquids together, like ink and water. They will automatically do the simple chemical process of dispersing until they are perfectly mixed," said Professor Shuichi Hiraoka of the University of Tokyo Graduate School of Arts and Sciences.

"However, there's no chemical process to automatically separate water and ink -- you need to boil the water into a gas to separate it from the ink," he added.

The new building blocks designed by Hiroka's team can connect or scramble themselves automatically because of the different temperature stabilities of the cubes that they form.

The two types of building blocks are nearly identical and are shaped like snowflakes. Researchers color them red or blue in schematic diagrams. A cube assembled from red blocks is stable below 130 degrees Celsius (266 degrees Fahrenheit), while a cube assembled from blue blocks is stable only below 65 degrees Celsius (149 degrees Fahrenheit).

When kept apart, the building blocks connect into entirely red or entirely blue uniform cubes.

When the two types of cubes are mixed together at room temperature (25 degrees Celsius, 77 degrees Fahrenheit), the red and blue building blocks automatically recombine into the most stable type of cubes, which are made of any combination of three red and three blue blocks. This mixture of red-blue cubes is analogous to well-mixed ink and water.

When researchers want to scramble the red-blue cubes to reform entirely red and entirely blue cubes, they do a simple two-step temperature change. This ability represents a chemical accomplishment not possible with a mixture of ink and water.

First, they heat the mixture up to boiling (100 degrees Celsius, 212 degrees Fahrenheit). The blue cubes become unstable and float off as individual molecules, while the red building blocks recombine into entirely red cubes.

Then, researchers rapidly cool the mixture (0 degrees Celsius, 32 degrees Fahrenheit) so that the red cubes stay together while the blue building blocks automatically assemble into entirely blue cubes.

Researchers can also prevent a mixture of entirely red and entirely blue cubes from scrambling into the more stable red-blue blended cubes by filling the cubes with something, for example other molecules like hydrocarbons. The guest molecules effectively lock the cubes closed from the inside so that the building blocks cannot scramble into other, more stable cube combinations.

"In the future, we plan to develop an even more complicated chemical system based on molecular cubes, using the unique self-assembly ability and a variety of energy sources beyond just heat," said Hiraoka.