Tumor microenvironment acts as a mechanism of resistance to chemotherapy

The study led by Dr David G. Molleví, researcher of the Program against cancer therapeutic resistance (PROCURE) of IDIBELL, reports how certain cytokines, chemokines and other soluble factors secreted by carcinoma associated fibroblasts (CAFs), a type of normal cell which is closely associated with primary tumor cells, induce processes that slow down cell cycle, affecting the proliferation of tumor cells. In the presence of conventional chemotherapy, such factors allow stabilization and activation of selected downstream proteins that minimize the effectiveness of the treatment. However, it has also been reported that inhibition of the JAK/STAT signaling pathway, addict to many of these cytokines, might revert the process.

The importance of tumor microenvironment (TME) as a relevant contributor to cancer progression and its role in the development of resistance to therapies has become increasingly apparent to researchers. "Although current cancer research mainly focuses on therapies against specific targets, most tumors are still treated with conventional cytotoxic therapies, so drug resistance remains the main obstacle to their success" explains Dr Molleví.

"From a clinical perspective, identifying the soluble factors that mediate such microenvironment-mediated drug resistance might yield valuable information to circumvent it," says Dr Molleví;. "Hampering key common, nomal cells responsible for the synthesis of such factors might be an interesting approach to avoid the protective effect exerted by such molecules and to render tumor cells sensitive to chemotherapy."