Wash your mouth out with silver, to treat hard-to-treat mouth infections?

Professor Henriques and her team, who recently published their research in the Society for Applied Microbiology's journal Letters in Applied Microbiology, looked at the use of different sizes of silver nanoparticles to determine their anti-fungal properties against Candida albicans and Candida glabrata. These two yeasts cause infections including oral thrush and dental stomatitis, a painful infection affecting around seven out of ten denture wearers. Infections like these are particularly difficult to treat because the microorganisms involved form biofilms.

The scientists used artificial biofilms in conditions which mimic those of saliva as closely as possible. They then added different sizes and concentrations of silver nanoparticles and found that different sizes of nanoparticles were equally effective at killing the yeasts. Due to the diversity of the sizes of nanoparticles demonstrating anti-fungal properties the researchers hope this will enable the nanoparticles to be used in many different applications.

Some researchers have expressed concerns around the safety of nanoparticle use but the authors stress this research is at an early stage and extensive safety trials will be carried out before any product reaches the market.

Professor Henriques comments: With the emergence of Candida infections which are frequently resistant to the traditional antifungal therapies, there is an increasing need for alternative approaches. So, silver nanoparticles appear to be a new potential strategy to combat these infections. As the nanoparticles are relatively stable in liquid medium they could be developed into a mouthwash solution in the near future.

Moving forward Professor Henriques hopes to integrate silver nanoparticles into dentures which could prevent infections from taking hold.