Bird Flu: Predictions Prompt Call For Antiviral Drugs To Be Shared

'Bird flu'(avian H5N1 influenza) has not triggered a worldwide human epidemic yet because it rarely passes between people. If it does acquire this ability, it would take 6-8 months to develop a vaccine effective against the new virus. Public health officials therefore need to consider how they would protect people during the first few months of a pandemic. Measures might include the use of antiviral drugs and international travel restrictions.

In a new study published in PLoS Medicine, researchers use detailed information on air travel to model the global spread of an emerging influenza pandemic and its containment. They conclude that much will depend on the 'reproductive number' (a measure of how many people an infectious individual infects on average) of the new virus that emerges. If this number is low, it will take many months before the virus spreads w orldwide and there will be plenty of time to bring an effective vaccine into use. But if the number is high then it could be difficult or impossible to contain the virus with vaccination.

Other measures could therefore be crucial, but it is likely that only a few countries will be able to stockpile supplies of drugs active against the virus. In these circumstances, compared with a 'selfish strategy' in which countries use their antiviral drugs only within their borders, limited worldwide sharing of antiviral drugs would slow down the spread of a flu virus by many months, to the benefit of both drug donors and recipients.

Citation: Colizza V, Barrat A, Barthelemy M, Valleron AJ, Vespignani A (2007) Modeling the worldwide spread of pandemic influenza: Baseline case and containment interventions. PLoS Med 4(1): e13. (http://dx.doi.org/10.1371/journal.pmed.0040013)