Mind & Brain News

November 26, 2025

Top Headlines

A Hidden Brain Energy Signal Drives Depression and Anxiety

Nov. 26, 2025 Scientists discovered that lowered brain energy signaling in the hippocampus can lead to both depression- and anxiety-like behaviors in mice. Stress reduced ATP, a molecule important for cell energy and communication. Altering a protein called ...

The Body Trait That Helps Keep Your Brain Young

Nov. 25, 2025 Scientists discovered that more muscle and less hidden abdominal fat are linked to a younger biological brain age. Deep visceral fat appeared to accelerate brain aging, while muscle mass offered a protective ...

Scientists Find a Hidden Weak Spot That May Trigger Alzheimer’s

Nov. 25, 2025 Scientists have found that a mutation tied to Alzheimer’s disrupts the production and quality of exosomes—tiny cell-made communication packets. Cells with the defective SORLA protein generate fewer exosomes and ones far less able to support ...

Your Brain Shows Damage Before Your Blood Pressure Even Rises

Nov. 24, 2025 Hypertension begins harming the brain surprisingly early, even before measurable blood pressure increases. Key cells related to blood vessels, signaling, and myelin maintenance begin aging prematurely and malfunctioning. These disruptions resemble ...

A Tiny Enzyme May Hold the Key to Safer Pain Relief

Nov. 23, 2025 Researchers have uncovered a surprising way the brain switches pain on, revealing that neurons can release an enzyme outside the cell that activates pain signals without disrupting normal movement or sensation. This enzyme, called VLK, modifies ...

Boosting One Protein Helps the Brain Protect Itself from Alzheimer’s

Nov. 23, 2025 Researchers discovered that raising the protein Sox9 can help the brain’s astrocytes clear out toxic plaque buildup linked to Alzheimer’s. In mouse models that already showed memory problems, activating these cells improved cognitive ...

Hidden Microglia Switch Helps Protect the Brain from Alzheimer’s

Nov. 22, 2025 Scientists discovered that lowering a specific molecule helps microglia switch into a protective state that quiets brain inflammation in Alzheimer’s. A small group of these cells seems to have an outsized ability to keep the brain healthier. When ...

New Nasal Nanodrops Wipe Out Brain Tumors in Mice

Nov. 22, 2025 A new nasal-delivered nanotherapy shows promise against aggressive glioblastoma tumors. By activating the STING immune pathway using gold-core spherical nucleic acids, researchers were able to reach the brain without invasive surgery. When paired ...

Scientists Reveal a Hidden Hormone Switch for Learning

Nov. 21, 2025 Researchers uncovered how estrogen subtly reshapes learning by strengthening dopamine reward signals in the brain. Rats learned faster when estrogen levels were high and struggled when the hormone’s activity was blocked. The findings help explain ...

Simple Amino Acid Supplement Greatly Reduces Alzheimer’s Damage

Nov. 21, 2025 Researchers discovered that the common amino acid arginine can block harmful Aβ aggregation and reduce its toxic effects in Alzheimer’s disease models. In flies and mice, oral arginine lowered plaque levels, reduced inflammation, and improved ...

Simple Molecule Shows Remarkable Alzheimer’s Reversal in Rats

Nov. 19, 2025 Scientists have developed a new molecule that breaks down beta-amyloid plaques by binding to excess copper in the brain. The treatment restored memory and reduced inflammation in rats, while also proving non-toxic and able to cross the blood–brain ...

How to Keep Ozempic/Wegovy Weight Loss Without the Nausea

Nov. 18, 2025 Scientists are uncovering how GLP-1 drugs like Ozempic and Wegovy act on brain regions that control hunger, nausea, pleasure-based eating, and thirst. These discoveries may help create treatments that keep the benefits of weight loss while reducing ...

Latest Headlines

updated 1:45pm EST

How Personalized Algorithms Trick Your Brain Into Wrong Answers

Nov. 25, 2025 Personalized algorithms may quietly sabotage how people learn, nudging them into narrow tunnels of information even when they start with zero prior knowledge. In the study, participants using ...

Supercomputer Creates the Most Realistic Virtual Brain Ever

Nov. 18, 2025 Researchers have created one of the most detailed virtual mouse cortex simulations ever achieved by combining massive biological datasets with the extraordinary power of Japan’s Fugaku ...

Blocking One Enzyme May Break the Link Between Alcohol and Liver Disease

Nov. 18, 2025 Scientists discovered that alcohol activates a sugar-producing pathway in the body, creating fructose that may reinforce addictive drinking. The enzyme responsible, KHK, appears to drive both alcohol ...

A Surprising CBD Advance Calms Pain Without Side Effects

Nov. 18, 2025 Researchers developed a new nano-micelle formulation, CBD-IN, that finally gets CBD into the brain effectively. In mice, it relieved neuropathic pain quickly and didn’t cause the usual movement or ...

Daily Music Listening Linked to Big Drop in Dementia Risk

Nov. 17, 2025 Older adults who regularly listen to or play music appear to have significantly lower risks of dementia and cognitive decline. The data suggests that musical engagement could be a powerful, enjoyable ...

The Hidden Brain Bias That Makes Some Lies So Convincing

Nov. 17, 2025 People are more likely to believe lies when there’s the possibility of a reward. Neuroimaging shows that the brain shifts into reward or risk mode depending on whether the context involves a gain ...

Chimps Shock Scientists by Changing Their Minds With New Evidence

Nov. 16, 2025 Chimps may revise their beliefs in surprisingly human-like ways. Experiments showed they switched choices when presented with stronger clues, demonstrating flexible reasoning. Computational modeling ...

Smoking Cannabis With Tobacco May Disrupt the Brain’s “bliss Molecule”

Nov. 15, 2025 Scientists found that people who use both cannabis and tobacco show a distinct brain pattern tied to mood and stress regulation. Their scans revealed ...

Scientists Melt Early Protein Clumps and Shut Down Alzheimer’s Damage

Nov. 15, 2025 Researchers found that tau proteins don’t jump straight into forming Alzheimer’s-associated fibrils—first they assemble into soft, reversible clusters. When the clusters were dissolved, fibril ...

Your Anxiety May Be Controlled by Hidden Immune Cells in the Brain

Nov. 13, 2025 Researchers have uncovered surprising evidence that anxiety may be controlled not by neurons but by two dueling groups of immune cells inside the brain. These microglia act like biological ...

What Brain Scans Reveal About Soccer Fans’ Passion and Rage

Nov. 11, 2025 Researchers scanning soccer fans’ brains found that wins trigger bursts of reward activity while losses dampen control signals. The results show how loyalty and rivalry can override logic, turning ...

Clearing Brain Plaques Isn’t Enough to Heal Alzheimer’s

Nov. 11, 2025 Japanese researchers found that lecanemab, an amyloid-clearing drug for Alzheimer’s, does not improve the brain’s waste clearance system in the short term. This implies that nerve damage and ...

Scientists Find Brain Cells That Could Stop Alzheimer’s

Nov. 8, 2025 Researchers have identified special immune cells in the brain that help slow Alzheimer’s. These microglia work to reduce inflammation and block the spread of harmful proteins. They appear to ...

A 500-Million-Year-Old Brain "radar" Still Shapes How You See

Nov. 8, 2025 New research shows that the superior colliculus, a primitive brain region, can independently interpret visual information. This challenges long-held beliefs that only the cortex handles such complex ...

Mini Llama Proteins Show Promise for Alzheimer’s Treatment

Nov. 6, 2025 Miniature antibodies from camels and llamas can slip into the brain more easily than conventional drugs, offering a new way to treat disorders like Alzheimer’s and schizophrenia. Researchers say ...

Common Acne Drug May Protect Against Schizophrenia

Nov. 6, 2025 Scientists have discovered a surprising benefit of the acne drug doxycycline: it may lower the risk of schizophrenia. Teens prescribed the antibiotic were about one-third less likely to develop the ...

Scientists Find Hidden Brain Source That Fuels Dementia

Nov. 6, 2025 Weill Cornell researchers uncovered how free radicals from astrocyte mitochondria can fuel dementia. Using new compounds that target these radicals at their source, they slowed brain inflammation and ...

Walking May Be the Brain’s Best Defense Against Alzheimer’s

Nov. 4, 2025 Walking a few thousand steps daily may help hold off Alzheimer’s for years, a Mass General Brigham study found. Even moderate physical activity slowed both cognitive decline and the buildup of ...

A Groundbreaking Brain Map Could Revolutionize Parkinson’s Treatment

Nov. 3, 2025 Duke-NUS scientists unveiled BrainSTEM, a revolutionary single-cell map that captures the full cellular diversity of the developing human brain. The project’s focus on dopamine neurons provides ...

MIT Scientists Discover How the Brain Spins Back Into Focus

Nov. 4, 2025 Researchers at MIT’s Picower Institute found that rotating waves of brain activity help restore focus after distractions. In animal tests, these rotations predicted performance: full rotations ...

Common Antidepressant Found to Work in Just Two Weeks

Nov. 8, 2025 Sertraline (Zoloft) may relieve emotional symptoms of depression and anxiety within two weeks, while physical side effects stabilize later. The research highlights how antidepressants can act on ...

A Breakthrough Map Reveals How the Brain Really Works

Nov. 5, 2025 Scientists have shown that brain connectivity patterns can predict mental functions across the entire brain. Each region has a unique “connectivity fingerprint” tied to its role in cognition, ...

It Sounds Creepy, but These Scientific Breakthroughs Could Save Lives

Oct. 30, 2025 From mini-brains to spider-inspired gloves and wolf apple coatings, scientists are turning eerie-sounding experiments into real innovations that could revolutionize health and sustainability. ...

Scientists May Have Found How to Reverse Memory Loss in Aging Brains

Nov. 5, 2025 Virginia Tech researchers have shown that memory loss in aging may be reversible. Using CRISPR tools, they corrected molecular disruptions in the hippocampus and amygdala, restoring memory in older ...

Alzheimer’s Might Be Powered by a Broken Sleep-Wake Cycle

Nov. 3, 2025 Disrupted sleep patterns in Alzheimer’s disease may be more than a symptom—they could be a driving force. Researchers at Washington University found that the brain’s circadian rhythms are ...

Gum Disease May Quietly Damage the Brain, Scientists Warn

Oct. 29, 2025 People with gum disease may have higher levels of brain white matter damage, a new study finds. Researchers observed that participants with gum disease had significantly more white matter ...

Humans Evolved Faster Than Any Other Ape

Oct. 29, 2025 UCL scientists found that human skulls evolved much faster than those of other apes, reflecting the powerful forces driving our brain growth and facial flattening. By comparing 3D models of ape ...

Running Fixes What Junk Food Breaks in the Brain

Oct. 21, 2025 New research reveals that exercise counteracts the mood-damaging effects of a Western-style diet through specific gut and hormonal mechanisms. Running restored metabolites tied to mental well-being ...

Brain Fog During Menopause? Here’s What’s Really Going on

Oct. 21, 2025 Menopause brings profound shifts not just in hormones but in the very structure of the brain. Scientists have found that gray matter in regions tied to memory and thinking can shrink, while white ...

Scientists Detect Hidden Brain Damage Years Before MS Symptoms

Oct. 21, 2025 Scientists at UCSF have uncovered evidence that multiple sclerosis silently damages the brain years before diagnosis. By studying proteins in blood samples, they identified early immune signals and ...