Nanofiber sensor detects diabetes or lung cancer faster and easier

Il-Doo Kim, Associate Professor of Materials Science and Engineering Department at the Korea Advanced Institute of Science and Technology (KAIST), and his research team have recently published a cover paper entitled "Thin-Wall Assembled SnO₂ Fibers Functionalized by Catalytic Pt Nanoparticles and their Superior Exhaled Breath-Sensing Properties for the Diagnosis of Diabetes," in an academic journal Advanced Functional Materials (May 20th issue), on the development of a highly sensitive exhaled breath sensor by using hierarchical SnO₂ fibers that are assembled from wrinkled thin SnO₂ nanotubes.

In the paper, the research team presented a morphological evolution of SnO₂ fibers, called micro phase-separations, which takes place between polymers and other dissolved solutes when varying the flow rate of an electrospinning solution feed and applying a subsequent heat treatment afterward.

The morphological change results in nanofibers that are shaped like an open cylinder inside which thin-film SnO₂ nanotubes are layered and then rolled up. A number of elongated pores ranging from 10 nanometers (nm) to 500 nm in length along the fiber direction were formed on the surface of the SnO₂ fibers, allowing exhaled gas molecules to easily permeate the fibers. The inner and outer wall of SnO₂ tubes is evenly coated with catalytic platinum (Pt) nanoparticles. According to the research team, highly porous SnO₂ fibers, synthesized by eletrospinning at a high flow rate, showed five-fold higher acetone responses than that of the dense SnO₂ nanofibers created under a low flow rate. The catalytic Pt coating shortened the fibers' gas response time dramatically as well.

The breath analysis for diabetes is largely based on an acetone breath test because acetone is one of the specific volatile organic compounds (VOC) produced in the human body to signal the onset of particular diseases. In other words, they are biomarkers to predict certain diseases such as acetone for diabetes, toluene for lung cancer, and ammonia for kidney malfunction. Breath analysis for medical evaluation has attracted much attention because it is less intrusive than conventional medical examination, as well as fast and convenient, and environmentally friendly, leaving almost no biohazard wastes.

Various gas-sensing techniques have been adopted to analyze VOCs including gas chromatography-mass spectroscopy (GC-MS), but these techniques are difficult to incorporate into portable real-time gas sensors because the testing equipment is bulky and expensive, and their operation is more complex. Metal-oxide based chemiresistive gas sensors, however, offer greater usability for portable real-time breath sensors.

Il-Doo Kim said, "Catalyst-loaded metal oxide nanofibers synthesized by electrospinning have a great potential for future exhaled breath sensor applications. From our research, we obtained the results that Pt-coated SnO₂ fibers are able to identify promptly and accurately acetone or toluene even at very low concentration less than 100 parts per billion (ppb)."

The exhaled acetone level of diabetes patients exceeds 1.8 parts per million (ppm), which is two to six-fold higher than that (0.3-0.9 ppm) of healthy people. Therefore, a highly sensitive detection that responds to acetone below 1 ppm, in the presence of other exhaled gases as well as under the humid environment of human breath, is important for an accurate diagnosis of diabetes. In addition, Professor Kim said, "a trace concentration of toluene (30 ppb) in exhaled breath is regarded to be a distinctive early symptom of lung cancer, which we were able to detect with our prototype breath tester."

The research team has now been developing an array of breathing sensors using various catalysts and a number of semiconducting metal oxide fibers, which will offer patients a real-time easy diagnosis of diseases.