Microscopic eye movements vital for 20/20 vision

Researchers previously assumed that visual acuity was primarily determined by the optics of the eye and the anatomy of the retina. Now, researchers from the University of Rochester -- including Michele Rucci, a professor of brain and cognitive sciences, and Janis Intoy, a neuroscience graduate student at Boston University and a research assistant in Rucci's lab in Rochester -- show that small eye movements humans aren't even aware of making play a large role in humans' visual acuity. The research, published in the journal Nature Communications, may lead to improved treatments and therapies for vision impairments.

Unlike a stationary camera that takes a fixed photograph of the world, human eyes are constantly moving, taking in new pieces of a visual scene and continually changing the visual input to the retina.

"Humans are normally not aware that their eyes are always in motion, even when attempting to maintain a steady gaze on a point," Intoy says.

These gaze shifts, known as fixational eye movements, were once thought to be inconsequential because they are so small. But, they are large on a microscopic level, relative to the size of cells in the retina, and they shift the image across many receptors. Rucci and the members of his lab have progressively shown that these movements are critical to processes in the visual system.

In order to determine whether or not fixational eye movements affect visual acuity, Rucci and Intoy studied how these tiny eye movements affect a person's performance on one of the most common assessments of visual acuity: the Snellen eye chart. The Snellen eye chart consists of 11 lines of block letters in which each line displays an increasing number of letters in decreasing sizes. During a vision test, a person is asked to read the letters in the lines. If a person has normal visual acuity -- 20/20 vision -- she is able to read to at least line eight on the chart from a distance of 20 feet.

Poor outcomes on the Snellen eye chart test are commonly attributed to defects in optical, structural, and/or physiological properties of the eye; eye movements are rarely considered. Rucci and Intoy found, however, that fixational eye movements are key contributors to 20/20 vision. In fact, even though humans are not aware of making them, these eye movements are finely controlled and can allow people to read at least two lines further on the Snellen eye chart versus when eye movements are absent or impaired.

In order to measure visual acuity in the absence of fixational eye movements, the researchers stabilized the eye chart on observers' retinas by continually updating the display according to the eye movements, counteracting the movements' effects. That is, unlike during normal viewing, when the visual input changes with eye movements, Intoy and Rucci ensured that the image of the eye chart remained stationary on the retina. This led to a drastic reduction in visual acuity; the observers, who normally had 20/20 vision, were on average now only able to read to approximately line six of the Snellen eye chart, to the line indicating 20/30 vision.

"We found that achieving 20/20 vision is not only the outcome of good optics and a healthy retina but also fine motor control, to a level that eludes awareness," Rucci says. "Impairment in visual acuity may originate from eye movements, a factor that is presently not monitored at all."

Because of the large role fixational eye movements play in visual acuity, doctors should carefully consider and examine these movements in people with impaired visual acuity, such as myopia (nearsightedness) and hyperopia (farsightedness).

"Eye movement disorders and visual impairments often coexist in some conditions as well," Intoy says. "For example, poor fixational control is often found in patients with visual impairments like dyslexia, and visual impairments are often present in patients with motor abnormalities like Parkinson's disease."

In addition to shedding new light on the fundamental mechanisms involved in high-acuity vision in humans, these findings suggest that methods based on oculomotor training and motor rehabilitation may help improve visual acuity. These therapies could include having patients with motor disorders practice holding their gaze on stationary objects and practice precisely shifting their gaze between nearby objects.

"Therapies involving fixational eye movements generally wouldn't help compensate for deficits in the optics, structure, and physiological features of the eye," Intoy says. "It is presently unclear whether abnormal eye movements may be the cause of such deficits (or vice versa), but our study now indicates this is indeed possible. If eye movements and the properties of the eye are interrelated in this way, then therapies involving eye movements may be helpful in these cases."