How the brain remembers where you're heading to

A team headed by Dr. Lukas Kunz, Universitätsklinikum Freiburg, and Professor Nikolai Axmacher, Head of the Department of Neuropsychology at Ruhr-Universität Bochum, published their findings on 3 July 2019.

Experiments in virtual reality

Previous studies had demonstrated that brain oscillations show a characteristic pattern during navigation. Theta oscillations, during which brain activity changes at a frequency of approximately four hertz, appear to play a crucial role in this process. But it had not been fully understood how, exactly, they support spatial navigation.

In the experiments, the epilepsy patients learned to associate individual objects with specific locations in a virtual environment. For each of the acquired object-location associations, the researchers identified a characteristic brain activity pattern.

Subsequently, the participants had to remember which object was associated with which location. While they navigated to that location in the virtual environment, the brain reactivated the location-specific activity patterns. The reactivation of brain activity for different object-location pairs occurred at different points of time during the theta cycles. "Accordingly, theta oscillations may coordinate the reactivation of different memories and, moreover, may help distinguish between competing memories," says Lukas Kunz.

Searching for a biomarker for Alzheimer's

"Many disorders are associated with disorientation and memory loss; it is therefore vitally important to gain an understanding of the underlying neuronal mechanisms," explains Nikolai Axmacher. The Bochum-based researcher and his colleagues are hoping that these studies may help identify novel biomarkers for such neurological disorders.