Healthy fats improve nerve function in obese mice
Data support further investigation of diets rich in monounsaturated fats as potential treatment for common diabetes complication
- Date:
- March 18, 2019
- Source:
- Society for Neuroscience
- Summary:
- Swapping dietary saturated fats for monounsaturated fats reverses nerve damage and restores nerve function in male mice, finds new preclinical research. These data support further investigation of diets rich in healthy fats as a potential treatment for the nerve damage that occurs with diabetes, known as diabetic neuropathy.
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Swapping dietary saturated fats for monounsaturated fats reverses nerve damage and restores nerve function in male mice, finds new preclinical research published in JNeurosci. These data support further investigation of diets rich in healthy fats as a potential treatment for the nerve damage that occurs with diabetes, known as diabetic neuropathy.
Type 2 diabetes is associated with high-fat diets characterized by large amounts of saturated fats. In contrast, monounsaturated fatty acid-rich diets have been shown to have health benefits. Professor Eva Feldman and colleagues at the University of Michigan investigated how these two types of fats affect the progression of diabetic neuropathy, the most common complication of diabetes.
The researchers found switching mice from a saturated fat-based diet to a diet rich in monounsaturated fats derived from sunflower oil restored and protected nerve function in obese mice. Studying the beneficial effects of monounsaturated fats in sensory dorsal root ganglion neurons showed the intervention helped the cells maintain normal energy production.
These results suggest that interventions targeting dietary fats may provide a new therapeutic avenue for the treatment of diabetic neuropathy.
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Materials provided by Society for Neuroscience. Note: Content may be edited for style and length.
Journal Reference:
- Amy E. Rumora, Giovanni LoGrasso, John M. Hayes, Faye E. Mendelson, Maegan A. Tabbey, Julia A. Haidar, Stephen I. Lentz, Eva L. Feldman. The divergent roles of dietary saturated and monounsaturated fatty acids on nerve function in murine models of obesity. The Journal of Neuroscience, 2019; 3173-18 DOI: 10.1523/JNEUROSCI.3173-18.2019
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