Neural processing with trauma and adversity interact to increase core symptom of PTSD

"Understanding why some people develop intrusive thoughts of a stressful or traumatic event and others do not is an important step towards preventing and treating posttraumatic stress disorder," said Cameron Carter, MD, Editor of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

Due to the nature of real-life trauma, which happens randomly and encompasses many different kinds of adversity, it is impossible to examine how neural processing during natural events contributes to PTSD. Researchers at the University of Salzburg, Austria, have now completed the first study of two well-known risk factors of PTSD, using fMRI to measure brain function during experimental trauma. After watching disturbing films of severe interpersonal violence, the study participants reported how often they experienced intrusive memories of the films, and how distressing the memories were. "This allowed us to study how the brain deals with intensely emotional events," said lead author Julina Rattel, MSc, a PhD student in the laboratory of senior author Frank Wilhelm, PhD.

"We found that increased brain activation in specific neural networks implicated in threat processing, emotion regulation, and memory encoding and consolidation predicted distressing recollections; though, this was only the case in individuals reporting several lifetime adversities, such as car accidents, assault, physical and sexual abuse, or natural disaster," said Ms. Rattel.

"This suggests that both previous experience and the level of neural activity in the brain during an event interact to determine whether a person will have subsequent trauma-related symptoms following a traumatic experience," said Dr. Carter.

Both neural processing and lifetime adversity have been considered risk factors for PTSD, but this is the first study to investigate the individual effects of each of these factors, and how they interact to produce a synergistic effect. "It has long been known that repeated 'hits' increase vulnerability to develop PTSD. Our results point to specific vulnerable brain networks that appear to have been sensitized by these hits, subsequently leading to PTSD-like symptoms when reactivated," said Ms. Rattel.