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Zika in high resolution

Date:
June 26, 2018
Source:
Cell Press
Summary:
The highest-resolution image yet of the Zika virus, or any enveloped virus thus far. The scientists used the latest electron microscopy techniques to see the atomic details of the Zika virus structure. They took advantage of Zika virus stability compared to its flavivirus cousins, allowing for a particularly accurate three-dimensional atomic model.
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The highest-resolution image yet of the Zika virus, or any enveloped virus thus far, appears June 26 in the journal Structure.

The scientists, Madhumati Sevvana, Feng Long, Andrew S. Miller, Thomas Klose, Geeta Buda, Lei Sun, Richard J. Kuhn, and Michael G. Rossmann, used the latest electron microscopy techniques to see the atomic details of the Zika virus structure.

They took advantage of Zika virus stability compared to its flavivirus cousins, such as dengue virus, Japanese encephalitis virus, and yellow fever virus, allowing for a particularly accurate three-dimensional atomic model.

"With the higher resolution, it is now possible to efficiently design vaccines and engineer anti-viral compounds that inhibit the virus," says Michael G. Rossmann, a structural biologist at Purdue University.

The research was supported by the National Institutes of Health.


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Journal Reference:

  1. Madhumati Sevvana, Feng Long, Andrew S. Miller, Thomas Klose, Geeta Buda, Lei Sun, Richard J. Kuhn, Michael G. Rossmann. Refinement and Analysis of the Mature Zika Virus Cryo-EM Structure at 3.1 Å Resolution. Structure, 2018; DOI: 10.1016/j.str.2018.05.006

Cite This Page:

Cell Press. "Zika in high resolution." ScienceDaily. ScienceDaily, 26 June 2018. <www.sciencedaily.com/releases/2018/06/180626113312.htm>.
Cell Press. (2018, June 26). Zika in high resolution. ScienceDaily. Retrieved December 24, 2024 from www.sciencedaily.com/releases/2018/06/180626113312.htm
Cell Press. "Zika in high resolution." ScienceDaily. www.sciencedaily.com/releases/2018/06/180626113312.htm (accessed December 24, 2024).

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