People with psychotic-like experiences spend less time in healthy brain states

Previous studies of PLEs have found alterations in specific brain networks, but the findings reveal that it is not just about damaged connections -- the amount of time spent in uncommon brain states may contribute to psychosis..

"These altered brain dynamics are important because they provide a new biomarker for subclinical psychosis," said Dr. Anita Barber of the Feinstein Institute for Medical Research in New York, first author of the study. The participants were all considered healthy, yet their subtle symptoms demonstrated unique brain fluctuations that could potentially be used to identify signs of psychosis.

In the study, Dr. Barber and colleagues analyzed brain imaging data from the Human Connectome Project of 76 otherwise healthy participants reporting PLEs and 153 control participants. Those experiencing PLEs spent less time in a more "typical" reoccurring brain state involving cognitive networks. They also spent more time in a state characterized by excessive communication in visual regions of the brain, which could be the basis for visual hallucinations experienced in psychosis. The study didn't include people with a psychotic disorder, but the findings line up with brain alterations found in patients with schizophrenia.

According to Dr. Cameron Carter, Editor of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, the study is an important example of how more sophisticated approaches to analyzing brain imaging data examining transitions between mental states over time can measure altered brain dynamics that can identify subtle risk states or even track the transition from subclinical to clinical psychopathology.

"This has implications for improving health and well-being and for preventing conversion to a psychotic disorder," said Dr. Barber. PLEs affect many more people than the number who will be diagnosed with a psychotic disorder, and can cause impairments in social and occupational functioning similar to, though less severe than, those experienced by people with psychosis. "The findings suggest that therapies encouraging greater engagement of goal-directed behaviors and less engagement of visual sensory processing could improve outcomes," said Dr. Barber.