Zika virus kills brain cells impairs intra uterine growth of mice fetuses
- Date:
- May 11, 2016
- Source:
- University of Sao Paulo Scientific Outreach Unit
- Summary:
- Researchers infected mice with the Zika virus circulating in Brazil, which resulted in fetuses impaired by congenital malformations resembling those observed in infants. Both in mice and in minibrains, virus infection causes extensive damage to neurological cells.
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The Zika virus strain circulating in Brazil was shown to be able to infect and cause damage to mice fetuses. In stem cell cultures of the human nervous system, the virus infection resulted in the cell death. Compared to the virus circulating in Africa, the Brazilian version appears more lethal to cells that later in development would give rise to the variety that makes up the brain.
The results will be published in the online edition of the journal Nature on Wednesday, in the article "The Brazilian Zika virus causes birth defects in experimental models," which reports experiments led by researchers from USP. In mice, the virus was able to cross the placenta of infected fetuses, restrict their overall growth, and cause the death of cells that form the brain of mice. The evidence supports the link between the infection by the Brazilian virus Zika in pregnant women, and congenital malformations such as microcephaly. This is the first animal model for the study of the Zika virus circulating in Brazil.
In vitro experiments demonstrate the effects of infection by the Brazilian and African Zika, and compares the damage of one and the other on three different types of human nervous system cell culture, including the so-called "minibrains." These lab-grown structures simulate the stage of development of human fetuses in the first trimester of pregnancy.
In minibrains, African virus and virus circulating in Brazil caused the death of nerve cells; after four days of infection, the Brazilian virus caused more extensive cell death and almost extinguished the proliferating cells, indicating that the viral strain present in Brazil -- originated in Asia -- has different behavior from the African lineage.
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Materials provided by University of Sao Paulo Scientific Outreach Unit. Note: Content may be edited for style and length.
Journal Reference:
- Fernanda R. Cugola, Isabella R. Fernandes, Fabiele B. Russo, Beatriz C. Freitas, João L. M. Dias, Katia P. Guimarães, Cecília Benazzato, Nathalia Almeida, Graciela C. Pignatari, Sarah Romero, Carolina M. Polonio, Isabela Cunha, Carla L. Freitas, Wesley N. Brandão, Cristiano Rossato, David G. Andrade, Daniele de P. Faria, Alexandre T. Garcez, Carlos A. Buchpigel, Carla T. Braconi, Erica Mendes, Amadou A. Sall, Paolo M. de A. Zanotto, Jean Pierre S. Peron, Alysson R. Muotri, Patricia C. B. Beltrão-Braga. The Brazilian Zika virus strain causes birth defects in experimental models. Nature, 2016; DOI: 10.1038/nature18296
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