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Molecular container gives drug dropouts a second chance
- Date:
- May 13, 2012
- Source:
- University of Maryland
- Summary:
- Chemists have designed a molecular container that can hold drug molecules and increase their solubility, in one case up to nearly 3,000 times.
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FULL STORY
A cross-disciplinary team of researchers at the University of Maryland has designed a molecular container that can hold drug molecules and increase their solubility, in one case up to nearly 3000 times. Their discovery opens the possibility of rehabilitating drug candidates that were insufficiently soluble. It also offers an opportunity to improve successful drugs that could be made even better with better solubility.
Story Source:
Materials provided by University of Maryland. Note: Content may be edited for style and length.
Journal Reference:
- Da Ma, Gaya Hettiarachchi, Duc Nguyen, Ben Zhang, James B. Wittenberg, Peter Y. Zavalij, Volker Briken, Lyle Isaacs. Acyclic cucurbit[n]uril molecular containers enhance the solubility and bioactivity of poorly soluble pharmaceuticals. Nature Chemistry, 2012; DOI: 10.1038/nchem.1326
Cite This Page:
University of Maryland. "Molecular container gives drug dropouts a second chance." ScienceDaily. ScienceDaily, 13 May 2012. <www.sciencedaily.com
University of Maryland. (2012, May 13). Molecular container gives drug dropouts a second chance. ScienceDaily. Retrieved October 9, 2025 from www.sciencedaily.com
University of Maryland. "Molecular container gives drug dropouts a second chance." ScienceDaily. www.sciencedaily.com
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