Mussel adhesive inspires tough coating for living cells

Insung S. Choi and colleagues say their simple method for coating the yeast cells could "serve as a new strategy for controlling cell division and protection of artificial spore like structures in a designed way." The technique could be used to encapsulate individual cells for a variety of purposes, including the creation of tiny chemical probes, single-cell chemical factories, and perhaps armor for transplanted cells used in anti-cancer therapies.

The new coating is an organic material called polydopamine, chemically similar to mussel adhesive. In laboratory experiments, the coating slowed down cell division in the yeast, while protecting them from cell-digesting chemicals. "We believe that polydopamine encapsulation would be a good starting point for both fundamental research and applications based on artificial spores," Choi and colleagues note in their study, "as it endows living cells with durability against harsh environments, controllability in cell cycles, and reactivity for cell-surface modification."