Expert analysis refutes claims that humans are colonized by bacteria before birth
Leading experts from several scientific disciplines find flaws in studies that suggest the existence of a 'fetal microbiome.'
- Date:
- January 25, 2023
- Source:
- University College Cork
- Summary:
- Scientific claims that babies harbor live bacteria while still in the womb are inaccurate, and may have impeded research progress, according to new research/
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Scientific claims that babies harbour live bacteria while still in the womb are inaccurate, and may have impeded research progress, according to University College Cork (UCC) researchers at APC Microbiome Ireland, a world-leading Science Foundation Ireland (SFI) Research Centre, which led a perspective published today (16.00 hrs GMT 25TH January) in the journal Nature.
Prior claims that the human placenta and amniotic fluid are normally colonised by bacteria would, if true, have serious implications for clinical medicine and paediatrics and would undermine established principles in immunology and reproductive biology.
To examine these claims, UCC & APC Principal Investigator Prof. Jens Walter assembled a trans-disciplinary team of 46 leading experts in reproductive biology, microbiome science, and immunology from around the world to evaluate the evidence for microbes in human fetuses.
A healthy human fetus is sterile
The team unanimously refuted the concept of a fetal microbiome and concluded that the detection of microbiomes in fetal tissues was due to contamination of samples drawn from the womb. Contamination occurred during vaginal delivery, clinical procedures or during laboratory analysis.
In the report in Nature, the international experts encourage researchers to focus their studies on the microbiomes of mothers and their newborn infants and on the microbial metabolites crossing the placenta which prepare the fetus for post-natal life in a microbial world.
According to Prof. Walter: "This consensus provides guidance for the field to move forward, to concentrate research efforts where they will be most effective. Knowing that the fetus is in a sterile environment, confirms that colonisation by bacteria happens during birth and in early post-natal life, which is where therapeutic research on modulation of the microbiome should be focused."
The expert international authors also provide guidance on how scientists in the future can avoid pitfalls of contamination in the analysis of other samples where microbes are expected to be absent or present at low levels, such as internal organs and tissues within the human body.
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Materials provided by University College Cork. Note: Content may be edited for style and length.
Journal Reference:
- Katherine M. Kennedy, Marcus C. de Goffau, Maria Elisa Perez-Muñoz, Marie-Claire Arrieta, Fredrik Bäckhed, Peer Bork, Thorsten Braun, Frederic D. Bushman, Joel Dore, Willem M. de Vos, Ashlee M. Earl, Jonathan A. Eisen, Michal A. Elovitz, Stephanie C. Ganal-Vonarburg, Michael G. Gänzle, Wendy S. Garrett, Lindsay J. Hall, Mathias W. Hornef, Curtis Huttenhower, Liza Konnikova, Sarah Lebeer, Andrew J. Macpherson, Ruth C. Massey, Alice Carolyn McHardy, Omry Koren, Trevor D. Lawley, Ruth E. Ley, Liam O’Mahony, Paul W. O’Toole, Eric G. Pamer, Julian Parkhill, Jeroen Raes, Thomas Rattei, Anne Salonen, Eran Segal, Nicola Segata, Fergus Shanahan, Deborah M. Sloboda, Gordon C. S. Smith, Harry Sokol, Tim D. Spector, Michael G. Surette, Gerald W. Tannock, Alan W. Walker, Moran Yassour, Jens Walter. Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies. Nature, 2023; 613 (7945): 639 DOI: 10.1038/s41586-022-05546-8
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