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Type 1 diabetes can be predicted with epigenetic changes

Date:
March 16, 2022
Source:
University of Turku
Summary:
Children who develop type 1 diabetes show epigenetic changes in the cells of their immune system before the antibodies of the disease are detected in their blood. The findings of two new studies offer new opportunities to identify the children with the genetic risk for developing diabetes very early on.
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Children who develop type 1 diabetes show epigenetic changes in the cells of their immune system already before the antibodies of the disease are detected in their blood. The findings of two new studies offer new opportunities to identify the children with the genetic risk for developing diabetes very early on.

Epigenetic changes can affect how our genes work. Environmental factors, such as viral infections, can cause epigenetic changes.

The findings in the epigenetic makeup linked to diabetes were discovered in two new studies led by researchers from Turku Bioscience at the University of Turku, Finland.

"We uncovered previously unknown, early-onset epigenetic changes. They offer us new opportunities to further develop ways to identify children who have a risk of developing type 1 diabetes even before they get sick," says Professor Riitta Lahesmaa, Director of Turku Bioscience and a group leader in the InFLAMES research flagship initiative.

Earlier studies have shown that certain antibodies detected in children's blood samples indicate an increased risk of developing type 1 diabetes in the near future. So that medical professionals could intervene in the disease even sooner, earlier disease indicators than the antibodies are needed to detect the risk. This involves searching for biomarkers indicating type 1 diabetes, and epigenetic changes could be such a biomarker.

"Our observations on epigenetics are extremely important as our goal is to develop methods and tools to prevent the onset of type 1 diabetes in children who are at risk of developing the disease," says Professor Laura Elo. Elo is the Director of the Medical Bioinformatics Centre at Turku Bioscience and a group leader in the InFLAMES research flagship.

Finnish children have an increased risk of developing type 1 diabetes

In Finland, children's risk of developing type 1 diabetes is the highest in the world. In addition to the genetic susceptibility, environmental factors have a great significance for developing the disease. The environmental factors include, for example, excessive level of hygiene, biodiversity loss, and environmental toxins.

The newly published studies are based on long-term interdisciplinary research collaboration with international partners. The project has included doctors who are in charge of the patients and also conduct clinical research, researchers in molecular medicine and immunology, and experts in computational science. In the studies, researchers analysed longitudinal samples with deep sequencing covering the entire genome as well as with computational methods and artificial intelligence.

"Our research was enabled by close collaboration with Professor Mikael Knip from the University of Helsinki, who coordinates a study funded by the EU. He is also one of the key scientists in the national Type 1 Diabetes Prediction and Prevention (DIPP) project which was a partner in the other study," highlights Professor Lahesmaa.

The studies were funded by the Academy of Finland, Juvenile Diabetes Research Foundation (USA), European Union, Business Finland, Novo Nordisk, and InFLAMES Flagship.


Story Source:

Materials provided by University of Turku. Note: Content may be edited for style and length.


Journal References:

  1. Tomi Suomi, Ubaid Ullah Kalim, Omid Rasool, Asta Laiho, Henna Kallionpää, Mari Vähä-Mäkilä, Mirja Nurmio, Juha Mykkänen, Taina Härkönen, Heikki Hyöty, Jorma Ilonen, Riitta Veijola, Jorma Toppari, Mikael Knip, Laura L. Elo, Riitta Lahesmaa. Type 1 Diabetes in Children With Genetic Risk May Be Predicted Very Early With a Blood miRNA. Diabetes Care, 2022; DOI: 10.2337/dc21-2120
  2. Inna Starskaia, Essi Laajala, Toni Grönroos, Taina Härkönen, Sini Junttila, Roosa Kattelus, Henna Kallionpää, Asta Laiho, Veronika Suni, Vallo Tillmann, Riikka Lund, Laura L. Elo, Harri Lähdesmäki, Mikael Knip, Ubaid Ullah Kalim, Riitta Lahesmaa. Early DNA methylation changes in children developing beta cell autoimmunity at a young age. Diabetologia, 2022; DOI: 10.1007/s00125-022-05657-x

Cite This Page:

University of Turku. "Type 1 diabetes can be predicted with epigenetic changes." ScienceDaily. ScienceDaily, 16 March 2022. <www.sciencedaily.com/releases/2022/03/220316100429.htm>.
University of Turku. (2022, March 16). Type 1 diabetes can be predicted with epigenetic changes. ScienceDaily. Retrieved November 20, 2024 from www.sciencedaily.com/releases/2022/03/220316100429.htm
University of Turku. "Type 1 diabetes can be predicted with epigenetic changes." ScienceDaily. www.sciencedaily.com/releases/2022/03/220316100429.htm (accessed November 20, 2024).

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