Long-term blood pressure variation and risk of dementia

The authors studied 5,273 people in Rotterdam, the Netherlands at a mean age of 67.6 years, who were free of dementia at the beginning of the study and were followed-up for 14.6 years. After adjustment for age, sex and other factors that could affect the findings, at 15 years people in the highest quintile, who exhibited an increase in systolic blood pressure, had a hazard ratio of 3.31 (95% Confidence Interval 2.11-5.18) for risk of dementia as compared with those in the quintile with the least change in blood pressure. Those in the lowest quintile, with the largest fall in systolic blood pressure, had a hazard ratio of 2.20 (95% CI 1.33-3.63) for dementia risk, again compared to those with the least change. Variations in both systolic and diastolic blood pressure led to similar findings.

Assuming that Hofman and colleagues' findings reflect a causal relationship between blood pressure variation and dementia, the authors note a "potential to prevent dementia through targeting blood pressure variability above and beyond the mere control of conventional blood pressure limits," and note that the association observed over a long time period implies that interventions should be implemented earlier in life to yield potential benefits.