Creating more potent cancer therapy using 'theranostics'

Key to the process are molecules called metallocorroles, which serve as versatile platforms for the development of drugs and imaging agents. City of Hope's John Termini, Ph.D., and his colleagues at the California Institute of Technology and the Israel Institute of Technology developed a novel method to prepare cell-penetrating nanoparticles called "metallocorrole/protein nanoparticles." The theranostics could both survive longer in the body and better snipe disease targets.

"This study is just one of City of Hope's many ongoing research projects that aim to move the field from conventional medicine to precision medicine, where therapies are tailored for specific individuals," said Termini, a molecular medicine professor at City of Hope.

The study, published in Scientific Reports, a Nature publication, on Feb. 19, details a unique way the researchers prepared the theranostics that may be generalizable to many similar molecules.

"Through collaborative brainpower, we were able to create something that has huge chemotherapeutic potential," Termini said. "Down the road, theranostics such as this could shorten treatment duration and diminish the dreaded side effects so many cancer patients fear."

The study was supported by an international collaboration grant from the Jacki and Bruce Barron Cancer Research Scholars' Program, The Harvey L. Miller Family Foundation, the National Institutes of Health and the Caltech/City of Hope Biomedical Initiative.