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Promising strategy to fight the most deadly brain tumor in children

Treatment slows tumor growth and increases survival in animal model of diffuse intrinsic pontine glioma (DIPG)

Date:
March 4, 2019
Source:
Ann & Robert H. Lurie Children's Hospital of Chicago
Summary:
A study found that an inhibitor of an enzyme called ACVR1 slows tumor growth and increases survival in an animal model of diffuse intrinsic pontine glioma (DIPG) -- the most deadly brain tumor in children.
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A study published in Nature Communications found that an inhibitor of an enzyme called ACVR1 slows tumor growth and increases survival in an animal model of diffuse intrinsic pontine glioma (DIPG) -- the most deadly brain tumor in children. Currently, there are no approved drugs for treating DIPG. This research opens the door to a promising new treatment strategy.

"Our results are encouraging and suggest that it might be reasonable to test an inhibitor of this enzyme in a clinical trial," says senior author Oren Becher, MD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and Associate Professor of Pediatrics at Northwestern University Feinberg School of Medicine. "Prior to that, we need to evaluate different ACVR1 inhibitors in animal models to make sure we bring the most safe and effective agent to trials with children."

In 2014, Dr. Becher's lab co-discovered that ACVR1 mutations are found in approximately 25 percent of DIPGs, leading the enzyme to be overactive. In the current study, Dr. Becher and colleagues demonstrate for the first time in an animal model that this enzyme mutation cooperates with a histone mutation (H3.1 K27M) found in 20 percent of DIPGs. Together, these mutations are important in initiating tumor development.

Histone is a protein that acts like a spool for DNA, helping to package the six-foot long DNA strand into the tiny nucleus of every cell. Histones also help regulate which genes turn on and off, a process that goes awry when there is a histone mutation.

"Our future work will examine why and how the ACVR1 and histone mutations work together to trigger DIPG development," says Dr. Becher, who also is the Rory David Deutsch Malignant Brain Tumor Research Scholar. "Greater insight into this process will bring us closer to identifying a successful therapy for children with DIPG."


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Materials provided by Ann & Robert H. Lurie Children's Hospital of Chicago. Note: Content may be edited for style and length.


Journal Reference:

  1. Christine M. Hoeman, Francisco J. Cordero, Guo Hu, Katie Misuraca, Megan M. Romero, Herminio J. Cardona, Javad Nazarian, Rintaro Hashizume, Roger McLendon, Paul Yu, Daniele Procissi, Samantha Gadd, Oren J. Becher. ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-08823-9

Cite This Page:

Ann & Robert H. Lurie Children's Hospital of Chicago. "Promising strategy to fight the most deadly brain tumor in children." ScienceDaily. ScienceDaily, 4 March 2019. <www.sciencedaily.com/releases/2019/03/190304100005.htm>.
Ann & Robert H. Lurie Children's Hospital of Chicago. (2019, March 4). Promising strategy to fight the most deadly brain tumor in children. ScienceDaily. Retrieved March 29, 2024 from www.sciencedaily.com/releases/2019/03/190304100005.htm
Ann & Robert H. Lurie Children's Hospital of Chicago. "Promising strategy to fight the most deadly brain tumor in children." ScienceDaily. www.sciencedaily.com/releases/2019/03/190304100005.htm (accessed March 29, 2024).

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