Immunological scarring from celiac disease
Celiac disease can cause irreversible changes to immune cells
- Date:
- February 14, 2019
- Source:
- Cardiff University
- Summary:
- Immune cells in the bowel of people who suffer with celiac disease are permanently replaced by a new subset of cells that promote inflammation, suggests a new study.
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Immune cells in the bowel of people who suffer with celiac disease are permanently replaced by a new subset of cells that promote inflammation, suggests a new study involving researchers at Cardiff University.
This permanent 'immunological scarring' lays the foundation for the disease to progress and could have long-term implications for gut health in affected patients.
The results also suggest that the same process could be contributing to other chronic intestinal disorders, such as ulcerative colitis.
Dr James McLaren, from Cardiff University's School of Medicine, said: "In celiac disease, T cells found in the bowel react to gluten and cause inflammation, which damages the lining of the bowel.
"Under normal circumstances, T cells have a protective role in the bowel and form a stable population. However, in celiac disease, they contribute to the inflammatory process, causing short-term symptoms and increasing the risk of developing certain types of bowel cancer.
"Our new study suggests that even though short-term symptoms, such as diarrhea and abdominal pain, can be alleviated by removing gluten from the diet, long-term implications may remain, because 'tissue-healing' T cells in the bowel are permanently replaced by 'pro-inflammatory' T cells."
Celiac disease is common and affects one in 100 people. The international team hope the new findings will help inform the treatment of chronic intestinal disorders.
Story Source:
Materials provided by Cardiff University. Note: Content may be edited for style and length.
Journal Reference:
- Toufic Mayassi, Kristin Ladell, Herman Gudjonson, James E. McLaren, Dustin G. Shaw, Mai T. Tran, Jagoda J. Rokicka, Ian Lawrence, Jean-Christophe Grenier, Vincent van Unen, Cezary Ciszewski, Matthew Dimaano, Hoda E. Sayegh, Vinod Kumar, Cisca Wijmenga, Peter H.R. Green, Ranjana Gokhale, Hilary Jericho, Carol E. Semrad, Stefano Guandalini, Aaron R. Dinner, Sonia S. Kupfer, Hugh H. Reid, Luis B. Barreiro, Jamie Rossjohn, David A. Price, Bana Jabri. Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Cell, 2019; DOI: 10.1016/j.cell.2018.12.039
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