How microbes emerged from hot springs to conquer early Earth: DNA exchange

Most extremophiles are microorganisms -- and many of the most extreme are archaea, an ancient group of single-celled organisms intermediate between the other two domains of life, bacteria and eukaryotes. Different archaea lineages are specialized to different extreme environments, including scalding hot springs, incredibly salty lakes, sunless deep-sea trenches and frigid Antarctic deserts. Only one branch, Thaumarchaeota, has managed to colonize very successfully the Earth's more hospitable places -- but scientists don't know why.

"Thaumarchaeota are found in very large numbers in virtually all environments, including the oceans, soils, plant leaves and the human skin," says Professor Christa Schleper from the University of Vienna, Austria, who guided and initiated the study. "We want to know what their secret is: billions of years ago, how did they adapt from hot springs, where it seems all archaea evolved, to more moderate habitats?"

As a starting point to answer this question, Professor Schleper and her team isolated a Thaumarchaeota species from a hot spring in Italy then sequenced and analyzed its genome. This represents the first genome analysis of the Nitroscaldus lineage -- a subgroup of heat-loving Thaumarchaeota that get their energy by oxidizing ammonia into nitrite.

The analysis revealed that the organism, Candidatus Nitrosocaldus cavascurensis, seems to represent the closest-related lineage to the last common ancestor of all Thaumarchaeota. Intriguingly, it has highly mobile DNA elements and seems to have frequently exchanged DNA with other organisms -- including other archaea, viruses and possibly even bacteria.

The ability to exchange genetic material could help this archaeon to rapidly evolve. "This organism seems prone to lateral gene transfer and invasion by foreign DNA elements," says Professor Schleper. "Such mechanisms may have also helped the ancestral lines of Thaumarchaeota to evolve and eventually radiate into moderate environments -- and N. cavascurensis may still be evolving through genetic exchange with neighboring organisms in its hot spring."

Many researchers assume that the first life forms on Earth evolved in hot springs. Further studies of this thermophile archaeon might help identify general mechanisms that enabled the first living cells, both bacteria and archaea, to conquer the world.