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Cryptococcal meningitis should be classified as a 'neglected tropical disease,' researchers say

Date:
July 25, 2017
Source:
University of St George's London
Summary:
Crytococcal meningitis is a deadly invasive fungal infection which affects hundreds of thousands of HIV patients in the late stage of their disease every year.
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Crytococcal meningitis is a deadly invasive fungal infection which affects hundreds of thousands of HIV patients in the late stage of their disease every year.

Attacking the tissues covering the brain and spinal cord, Cryptococcal meningitis is responsible for an estimated 15-20% of all AIDS-related deaths.

Yet it is one of the most poorly-funded diseases in the world, receiving just 0.2% of available relevant research and development investment.

It disproportionately affects populations in some of the poorest regions of the world, but it is not classified by the World Health Organisation as a 'neglected tropical disease', nor by other groups working in this field such as PLOS, an open access publishing and advocacy group.

Inclusion in the WHO's list of neglected tropical diseases would enable this infection to be eligible for WHO health programs aimed at eradicating diseases.

Now a new research paper: "Cryptococcal meningitis; A neglected tropical disease?" argues that cryptococcal meningitis meets all the criteria for inclusion on the WHO list.

The WHO says neglected tropical diseases are 'a proxy for poverty and disadvantage'; have 'an important impact on morbidity and mortality'; and are relatively 'neglected by research'. In the paper the researchers demonstrate that all these criteria are fulfilled.

Drs Síle Molloy and Angela Loyse at St George's, University of London, are the principal authors of the report. Dr Molloy explained: "A common misconception is that funding for cryptococcal meningitis comes under the umbrella of HIV.

"In reality it has fallen into a research and policy gap. There are only three drug treatments, all of which are decades old and two of which are regularly unavailable. Meanwhile R&D into the manufacture of new therapies is inadequate."


Story Source:

Materials provided by University of St George's London. Note: Content may be edited for style and length.


Journal Reference:

  1. Síle F. Molloy, Tom Chiller, Gregory S. Greene, Jessica Burry, Nelesh P. Govender, Cecilia Kanyama, Sayoki Mfinanga, Sokoine Lesikari, Yacouba N. Mapoure, Charles Kouanfack, Victor Sini, Elvis Temfack, David R. Boulware, Francoise Dromer, David W. Denning, Jeremy Day, Neil R. H. Stone, Tihana Bicanic, Joseph N. Jarvis, Olivier Lortholary, Thomas S. Harrison, Shabbar Jaffar, Angela Loyse. Cryptococcal meningitis: A neglected NTD? PLOS Neglected Tropical Diseases, 2017; 11 (6): e0005575 DOI: 10.1371/journal.pntd.0005575

Cite This Page:

University of St George's London. "Cryptococcal meningitis should be classified as a 'neglected tropical disease,' researchers say." ScienceDaily. ScienceDaily, 25 July 2017. <www.sciencedaily.com/releases/2017/07/170725090102.htm>.
University of St George's London. (2017, July 25). Cryptococcal meningitis should be classified as a 'neglected tropical disease,' researchers say. ScienceDaily. Retrieved November 22, 2024 from www.sciencedaily.com/releases/2017/07/170725090102.htm
University of St George's London. "Cryptococcal meningitis should be classified as a 'neglected tropical disease,' researchers say." ScienceDaily. www.sciencedaily.com/releases/2017/07/170725090102.htm (accessed November 22, 2024).

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