High-fat diet alters reward system in rats

Dopamine is a neurotransmitter that plays an important role in sensitization -- the process by which repeated administration of a reward, being pharmacological such as amphetamine or natural such as highly palatable food, causes an increase in response to the reward.

In this study, Guillaume Ferreira and colleagues investigated the effects of high-fat diet exposure on sensitization to amphetamine, a psychostimulant acting through the dopamine system. The authors found that male rats fed a high-fat diet for three months, from weaning to adulthood, exhibited increased locomotor activity in response to a second injection of amphetamine, as well as increased activity of dopamine cells in the ventral tegmental area (VTA) and dopamine release in the nucleus accumbens (NAc). These findings reveal that the development of the VTA-NAc pathway during adolescence is influenced by a high-fat diet, which may lead to long-term changes in reward-seeking behavior.