Sometimes just watching hurts, and the signs of pain are seen in the brain

When you hurt yourself, pain receptors in the body send signals to different parts of the brain. As the result, you experience pain. Researchers in Aalto University, Finland, found that when CRPS patients feel pain caused by observing other person's movements, their brains display abnormal activation in many such areas that respond to normal physical pain. Thus the pain that the CRPS patients felt during movement observation presented similarities to the "normal" pain associated with tissue damage.

"CPRS is a very complex disease with devastating chronic pain. Its pathophysiology is incompletely understood and definitive biomarkers are lacking. Our discovery may help to develop diagnostics and therapeutic strategies for CRPS patients," tells neurologist Jaakko Hotta, Doctoral Candidate at Aalto University.

In the study, the researchers analyzed functional magnetic resonance images from 13 upper-limb CRPS patients and 13 healthy control subjects who were viewing brief videos of hand actions, such as a hand squeezing a ball with maximum force.

In the CPRS patients, watching hand actions was associated with abnormal brain activation patterns and a pattern-classification analysis differentiated the patients from the healthy subjects. These findings indicate that CRPS affects brain areas related to both pain processing and motor control.

The study was published on the Journal of Pain, the official journal of the American Pain Society.