Trabecular bone score validated as standalone predictor of fracture risk

In the largest such study to date, a team of international researchers have now validated the predictive ability of TBS using individual-level data of 17,809 men and women from 14 studies worldwide. They aimed to validate the contribution of TBS to fracture risk prediction, independent of FRAX, and to examine the impact of applying TBS adjustment to FRAX probabilities.

The study authors found that:

• TBS was consistently an independent contributor to the assessment of fracture risk and that the relationship with other risk factors was robust across sex, diverse races, fracture incidents, and geographical regions.
• The combination of TBS with the clinical risk factors (including BMD) showed enhanced gradients of risk for hip and non-hip major osteoporotic fractures compared with TBS or the FRAX risk factors alone.

Co-author Professor John A Kanis, Emeritus Professor in Human Metabolism, University of Sheffield, stated, "The findings of this study support the use of TBS, not only as a standalone assessment of fracture risk but also, more importantly, as an independent contributor to a more global risk assessment that could permit its use alongside established risk assessment tools such as FRAX."