Potential new target to prevent breast cancer relapse

Published in the journal Oncogene, the researchers have for the first time shown how a specific protein receptor on the surface of breast cells promotes the progression of breast cancer.

"Breast cancer is the most commonly diagnosed cancer in women worldwide and, despite great advances in treatment, mortality rates are still high," says Sarah Boyle, who is conducting this research as part of her PhD within the School of Biological Sciences.

"The initiation, growth and spread of breast cancer is believed to be under the control of a small number of specific cancer cells. These are cancer 'stem cells' -- a group of cells within the tumour that possess the properties of normal adult stem cells.

"They are slow-growing and do not divide quickly, and so are not eliminated by conventional breast cancer therapies which typically target rapidly-dividing cancer cells that constitute the bulk of the tumour. This persistence of cancer stem cells is believed to lead to cancer relapse. It is therefore very important to develop specific therapies directed against these cells."

The researchers have discovered that a protein called chemokine receptor CCR7 plays an important role in controlling breast cancer stem cells.

"This protein receptor, which is normally involved in regulation of the immune system, has been connected to the progression of different cancers in a number of studies," says Ms Boyle.

"In particular, it has been implicated in the growth and spread of breast cancer, but its function in breast cancer has not been clear.

"We found that CCR7 is involved in maintenance of the cancer stem cell pool as well as regulating their function, and therefore fuels the growth of breast cancer."

Project leader Dr Marina Kochetkova, Senior Research Officer in the School, says removal of the chemokine receptor in laboratory models produced a considerable delay in tumour onset, growth and spread.

"Developing drugs to modify the action of this receptor may pave the way for future therapeutic treatments to target these evasive cancer stem cells," Dr Kochetkova says.