Early treatment for nerve tumors prevents serious problems, study finds

Doctors typically treat larger forms of the tumors, called vestibular schwannomas, while taking a "watch and wait" approach to smaller tumors that aren't causing appreciable problems. But the new research, from UVA Health neurosurgeon Jason Sheehan, MD, PhD, and collaborators, could change how asymptomatic schwannomas are managed. Their findings demonstrated that stereotactic radiosurgery -- a highly targeted form of radiation therapy -- can prevent small tumors from growing over time while at the same time sparing patients from potentially irreversible problems in the future.

"This study and our recent Vestibular Schwannoma International Study of Active Surveillance versus Stereotactic Radiosurgery [VISAS] trial demonstrate that radiosurgery affords effective and durable tumor control while more often avoiding the neurological complications that come from watching a vestibular schwannoma," Sheehan said. "Over time, Gamma Knife radiosurgery bends the curve of growth and problems that commonly arise from watching even the smallest of vestibular schwannomas."

About Vestibular Schwannomas

Vestibular schwannomas are growths on a cranial nerve that connects the brain and inner ear. This nerve transmits information about head movements, helps us control our balance and allows us to hear. The growths, however, can disrupt the nerve's important functions, causing hearing loss, unsteadiness, headaches, tinnitus (ringing in the ear), facial numbness/paralysis and other problems.

Seeking to improve care for patients with these tumors, Sheehan and his team performed a trial through the International Radiosurgery Research Foundation looking at 261 adults with the smallest category of vestibular schwannomas. These were usually picked up early, and the patients often were high functioning and had the most to lose from tumor growth over time. Of the study participants, 182 received stereotactic radiosurgery, while 79 did not.

The patients who underwent radiosurgery using the Gamma Knife system showed consistently better tumor control over time. In this group, 99% of the patients' tumors either stayed the same size, grew very little (less than 25%) or shrank. This was true at 3 years, 5 years, and 8 years. Only one patient's tumor significantly increased in size.

Tumor control was much worse among those who didn't receive radiosurgery: 37% saw their tumors grow significantly at 3 years, 50% at five years, and 67% at eight years.

That difference was seen plainly in the symptoms the patients experienced. Radiosurgery was associated with a 54% lower rate of tinnitus, a 51% lower rate of cranial nerve deterioration and an 83% lower rate of vestibular dysfunction that causes dizziness and loss of balance.

Even with Gamma Knife radiosurgery to treat the tumor arising from this very delicate neural structure, hearing was preserved similarly in both groups.

Sheehan, an expert in stereotactic radiosurgery and brain tumors, urges physicians to take note of the findings because tumor symptoms are often irreversible as the tumor grows. Acting early, before symptoms develop, could greatly improve patients' long-term quality of life, he says.

"In brain surgery, particularly involving the hearing and balance nerve, our approach must be exceedingly refined," he said. "This study shows that Gamma Knife radiosurgery substantially improves the future trajectory of vestibular schwannoma patients."