A new breakthrough in understanding regeneration in a marine worm

Even more surprising, the team found that this ability of gut cells to regenerate other tissue varies according to their location: the closer they are to the posterior end of the worm, the greater the variety of cell types they can rebuild². This study will appear in Development on 2 July.

Scientists carried out these observations by monitoring the outcome of gut cells and proliferative cells that form close to the amputated end of the worm. This was tracked using different markers in particular by fluorescent beads ingested by the worms. Annelids, or 'segmented worms', which have only been studied in the last 20 years, are an ideal model for the study of regeneration, a process that is widespread in animals but still mysterious for scientists.

The research team will continue this work to determine whether cell types, other than gut cells, can play a role in regenerating a variety of cell types.

Notes

1 -- Working at the Institut Jacques Monod (CNRS/Université Paris Cité). Scientists at Inserm and Université Paris Cité also contributed to this research.

2 -- Only cells involved in the nervous system and growth zone of the worm (a ring of stem cells involved in the continuous growth of the animal until it reaches sexual maturity) cannot, it appears, be generated by gut cells found in the posterior end of the worm.