COVID vaccine booster increases antibody responses, is protective in rhesus macaques, study finds

The researchers also determined that both the mRNA-1273 vaccine developed to target the original SARS-CoV-2 virus and a slightly modified version of the vaccine targeting the Beta variant, were equivalent in their ability to boost antibody responses and protect. Scientists at the Vaccine Research Center, part of NIH's National Institute of Allergy and Infectious Diseases, led the project with collaborators from Emory University; Bioqual, Inc.; Moderna, Inc.; and Johns Hopkins University.

This study was performed six months ago when the SARS-CoV-2 Beta variant was a major concern. The researchers focused on the Beta variant because it has consistently shown the greatest ability to resist neutralization -- by likely reducing vaccine effectiveness -- according to the researchers. While Delta has become the dominant virus variant in the United States, because of its high transmissibility, it has only an intermediate ability to resist neutralization, the study authors state.

The scientists write that in people, an mRNA-1273 booster vaccine may improve the duration and potency of protection against upper and lower airway infection by any of the circulating SARS-CoV-2 variants, including Delta. They note that this would be especially important to maintain protection against severe disease and possibly limit mild infection and virus transmission. Their results support vaccine boosting in the elderly, people with pre-existing health conditions, those at high-risk exposure, and those who responded poorly to primary vaccination.