Autophagy: Scientists discover novel role for self-recycling process in the brain

Autophagy cleans the cells by breaking down and removing the damaged proteins and organelles, cell areas with a specific function. It is hardly surprising that this process is particularly important for long-lived cells such as neurons, since neurons are no longer capable of cell division ('post-mitotic') and are therefore particularly vulnerable to accumulating unfavorable proteins and damaged organelles. In their new study, the scientists show that neurons in the mouse brain do not need autophagy to survive. Instead, these specialized cells use autophagy proteins to regulate the microtubule-dependent transport of molecules crucial for learning and memory.

The fact that autophagy is crucial for the well-being of the brain is supported by scientific discoveries made over the last decade. Many studies have identified defective autophagy as one of the pathological causes of neurodegenerative diseases, including Alzheimer's (AD), Parkinson's and Huntington's disease. In this context, the novel function of autophagy the scientists discovered suggests that the therapeutic modulations of autophagy activity in patients might not only promote the waste clearance in the brain, but also alter the cognitive abilities by changing the efficiency of the intracellular transportation system.