Pathogen that causes sleeping sickness: Promising new target

Dr. Susanne Kramer and her team published the new findings in the journal PLOS Pathogens. "The enzyme is called TbALPH1," the researcher details. "It triggers the degradation of messenger RNA and is totally different from the enzymes responsible for this process in higher organisms."

The JMU researcher counts the Trypanosoma enzyme among the class of ApaH-like phosphatases which are of bacterial origin. Although this class of enzymes does not exist in vertebrates, it is found in other groups of animals. "We don't know yet which function the enzymes have there. So we want to study next whether ApaH-like phosphatases from other organisms are equally involved in degrading the messenger RNA," Kramer says.

Facts about sleeping sickness

Trypanosomes are wide-spread in sub-Saharan Africa. The worm-like parasites are transmitted by the bite of an infected tsetse fly. Each year, there are 30,000 new infections. Initial symptoms include headaches and joint pains followed by confusion, seizures and other symptoms in later stages. Finally, the sufferers fall into coma and die.

There are no vaccines available against the pathogens; the available drugs can have extreme side effects. So there is urgent demand for better medication to treat the disease. Trypanosomes not only infect humans. They also kill cattle, goats and other livestock thereby causing additional damage: In some regions of Africa, breeding livestock is hardly possible due to the trypanosomes.